[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT07717437":3,"trial-entities:NCT07717437":636,"trial-summary:NCT07717437":643},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":6,"overall_status":7,"completion_date":8,"status_verified_date":9,"last_update_date":10,"start_date":11,"sponsor_name":12,"lead_sponsor_class":13,"has_dmc":14,"brief_summary":15,"detailed_description":16,"conditions":17,"keywords":20,"study_type":40,"primary_purpose":41,"phases":42,"enrollment_info":43,"interventions":46,"primary_outcomes":47,"secondary_outcomes":51,"sex":90,"minimum_age":91,"maximum_age":41,"healthy_volunteers":14,"eligibility_criteria":92,"std_ages":99,"locations":102,"central_contacts":604,"overall_officials":606,"references":609,"see_also_links":635},"NCT07717437","2021-2578","DRAGON Registry - International Multicenter Registry and Medical Image Bank for Patients With Primarily Unresectable Liver Cancer or Liver Metastases That Underwent Combined Portal and Hepatic Vein Embolization (PVE\u002FHVE) to Increase Future Liver Remnant Before Resection.","RECRUITING","2032-11-30","2026-07","2026-07-21","2021-03-16","Maastricht University Medical Center","OTHER",false,"The DRAGON registry aims to collect data on combined portal and hepatic vein embolization (PVE\u002FHVE) for liver tumors, a technique expected to enhance liver regeneration compared to standard PVE. This collaborative registry focuses on identifying associations between baseline clinical\u002Fimaging parameters, clinical outcomes, and safety for patients undergoing PVE\u002FHVE.","Retrospective and prospective",[18,19],"Liver Cancer","Liver Metastases",[21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39],"Liver cancer","Liver metastases","Portal vein embolization","PVE","HVE","PVE\u002FHVE","Future liver remnant","Liver resection","Hepatectomy","Post-hepatectomy liver failure","Surgical oncology","Double Vein Embolisation","FLR","Liver Venous Deprivation","LVD","Hepatic Vein Embolization","Hepatocellular Carcinoma","Perihilar cholangiocarcinoma","Intrahepatic cholangiocarcinoma","OBSERVATIONAL",null,[],{"count":44,"type":45},350,"ESTIMATED",[],[48],{"measure":49,"timeFrame":50},"Resectability three weeks after PVE\u002FHVE and 5 years overall survival","From enrolment until 5 year follow up",[52,56,60,64,68,71,75,79,83,87],{"measure":53,"description":54,"timeFrame":55},"Number of complications during embolization","The number of complications occurring during liver embolization (e.g., spill to the future liver remnant).","Perioperative",{"measure":57,"description":58,"timeFrame":59},"Kinetic Growth Rate [%\u002Fweek]","Volumetric assessments are performed at baseline and three weeks after embolization. Changes in FLR volume will be standardized (sFLR) by calculating the ratio of the FLR to the Standardized Total Liver Volume (sTLV) using the Vauthey formula. The DH will be calculated as the percentage point difference in sFLR volume between baseline and three weeks after embolization. The KGR will then be derived from the DH, quantifying the weekly percentage volume increase observed between these measurements.","3 weeks after the embolization",{"measure":61,"description":62,"timeFrame":63},"Functional Growth Rate [%\u002Fweek]","The Functional Growth Rate reflects the rate at which FLR function increases after embolization, as measured by hepatobiliary scintigraphy. FLR function is expressed in %\u002Fmin\u002Fm2 at baseline and three weeks after embolization. The functional degree of hypertrophy (FDH-function) is the percentage point difference in FLR function between these time points, and the FGR is calculated by dividing the DH-function by the number of weeks elapsed.","Three weeks after the embolization",{"measure":65,"description":66,"timeFrame":67},"90-day survival after embolization","90-day survival is defined as the proportion of patients alive at 90 days after liver embolization, serving as a standard measure of short-term postoperative outcome and surgical safety.","90 days post-embolization \u002F post-resection",{"measure":69,"description":70,"timeFrame":55},"Number of complications during surgery","The number of complications occurring during liver surgery (e.g., excessive blood loss and vascular or biliary injury).",{"measure":72,"description":73,"timeFrame":74},"90 day survival after resection","90-day survival is defined as the proportion of patients alive at 90 days after liver surgery, serving as a standard measure of short-term postoperative outcome and surgical safety.","90 days",{"measure":76,"description":77,"timeFrame":78},"Clinical resection rates","The clinical resection rate is defined as the proportion of patients who undergo liver resection among those who started embolization.","Until MDT decision on resection (yes\u002Fno), approximately 3-6 weeks after the embolization",{"measure":80,"description":81,"timeFrame":82},"Number of salvage procedures","This outcome measure captures the proportion of patients in whom the FLR fails to reach a sufficient volume or function after the initial embolization procedure, and who therefore undergo an additional salvage intervention (e.g., repeat or completion embolization) to further promote FLR growth before resection can be considered","Approximately 3-6 weeks after the embolization",{"measure":84,"description":85,"timeFrame":86},"Number of participants with disease recurrence","The proportion of patients who develop disease recurrence (locoregional or distant) during follow-up after liver resection.","Until five years after the embolization\u002Fresection",{"measure":88,"description":89,"timeFrame":86},"Number of oncological interventions during follow up","The number of additional oncological interventions (e.g., chemotherapy, repeat liver resection, ablation, radiotherapy) administered to patients during follow-up","ALL","18 Years",{"inclusion":93,"exclusion":97,"raw_text":98},[94,95,96],"Patients who have undergone PVE\u002FHVE or technical variations on this procedure","18 Years and older","Men and women",[],"Inclusion Criteria:\n\n* Patients who have undergone PVE\u002FHVE or technical variations on this procedure\n* 18 Years and older\n* Men and women",[100,101],"ADULT","OLDER_ADULT",[103,123,136,152,170,187,199,217,233,249,266,284,300,317,332,348,363,379,395,412,428,445,460,476,491,503,521,537,552,573,587],{"facility":104,"status":7,"city":105,"state":106,"zip":107,"country":108,"contacts":109,"geoPoint":120},"Rush University Medical Center","Chicago","Illinois","60612","United States",[110,115,118],{"name":111,"role":112,"phone":113,"email":114},"Frannie Richards","CONTACT","+1 312-942-5000","frannie_l_richards@rush.edu",{"name":116,"role":117},"Matthew Dixon, Dr.","PRINCIPAL_INVESTIGATOR",{"name":119,"role":117},"Jordan Tasse, Dr.",{"lat":121,"lon":122},41.85003,-87.65005,{"facility":124,"status":7,"city":125,"state":126,"zip":127,"country":108,"contacts":128,"geoPoint":133},"Mayo Clinic","Rochester","Minnesota","55905",[129],{"name":130,"role":112,"phone":131,"email":132},"Yawen Dong, Dr.","+1 507-284-2511","InternationalCollaborate@mayo.edu",{"lat":134,"lon":135},44.02163,-92.4699,{"facility":137,"status":7,"city":138,"state":139,"zip":140,"country":108,"contacts":141,"geoPoint":149},"Cleveland Clinic","Cleveland","Ohio","44195",[142,146,147],{"name":143,"role":112,"phone":144,"email":145},"Federico Aucejo, Dr.","+1 216-444-2200","patientexperienceccl@ccf.org",{"name":143,"role":117},{"name":148,"role":117},"Sameer Gadani, Dr.",{"lat":150,"lon":151},41.4995,-81.69541,{"facility":153,"status":7,"city":154,"state":155,"zip":156,"country":157,"contacts":158,"geoPoint":167},"Monash Medical Centre","Clayton","Victoria","3168","Australia",[159,163,165],{"name":160,"role":112,"phone":161,"email":162},"Meenal Gupta","(03) 9594 6666","Meenal.Gupta@monashhealth.org",{"name":164,"role":117},"Diederick De Boo, Dr.",{"name":166,"role":117},"Daniel Croagh, Dr",{"lat":168,"lon":169},-37.91667,145.11667,{"facility":171,"status":7,"city":172,"state":173,"zip":174,"country":175,"contacts":176,"geoPoint":184},"MedUni Wien","Vienna","State of Vienna","1090","Austria",[177,181,182],{"name":178,"role":112,"phone":179,"email":180},"Johannes Längle, Dr.","+43 1 401600","aufnahmeverfahren@meduniwien.ac.at",{"name":178,"role":117},{"name":183,"role":117},"Fredrik Waneck, Dr.",{"lat":185,"lon":186},48.20849,16.37208,{"facility":188,"status":7,"city":172,"state":173,"zip":189,"country":175,"contacts":190,"geoPoint":198},"Social Center South (Klinik Favoriten)","1100",[191,195,196],{"name":192,"role":112,"phone":193,"email":194},"Thomas Grünberger, Prof. Dr.","+43 1 601910","kfn.post@gesundheitsverbund.at",{"name":192,"role":117},{"name":197,"role":117},"Ivan Baclija, Dr.",{"lat":185,"lon":186},{"facility":200,"status":7,"city":201,"state":202,"zip":203,"country":204,"contacts":205,"geoPoint":214},"UZ Antwerpen","Edegem","Antwerpen","2650","Belgium",[206,210,212],{"name":207,"role":112,"phone":208,"email":209},"Axelle Belis","+32 3 821 30 00","Axelle.Belis@uza.be",{"name":211,"role":117},"Thiery Chapelle, Prof. Dr.",{"name":213,"role":117},"Hendrik Verelst, Dr.",{"lat":215,"lon":216},51.15662,4.44504,{"facility":218,"status":7,"city":219,"state":220,"zip":221,"country":204,"contacts":222,"geoPoint":230},"Erasmus Hospital","Anderlecht","Brussels Capital","1070",[223,227,228],{"name":224,"role":112,"phone":225,"email":226},"Valerio Lucidi, Dr.","+32 2 555 31 11","valerio.lucidi@erasme.ulb.ac.be",{"name":224,"role":117},{"name":229,"role":117},"Desislava Germanova, Dr.",{"lat":231,"lon":232},50.83619,4.31454,{"facility":234,"status":7,"city":235,"state":235,"zip":236,"country":204,"contacts":237,"geoPoint":246},"CHU de Liège","Liège","4000",[238,242,244],{"name":239,"role":112,"phone":240,"email":241},"Axelle Bertrand","+32 4 323 00 00","Axelle.Bertrand@chuliege.be",{"name":243,"role":117},"Olivier Detry, Prof. Dr.",{"name":245,"role":117},"Laurent Gérard, Dr.",{"lat":247,"lon":248},50.63373,5.56749,{"facility":250,"status":7,"city":251,"state":252,"zip":253,"country":204,"contacts":254,"geoPoint":263},"UZ Gent","Ghent","Oost-Vlaanderen","9000",[255,259,261],{"name":256,"role":112,"phone":257,"email":258},"Lynn Huyck","+32 9 332 21 11","Lynn.Huyck@uzgent.be",{"name":260,"role":117},"Luís Abreu de Carvalho, Dr.",{"name":262,"role":117},"Laurens Hermie, Dr.",{"lat":264,"lon":265},51.05,3.71667,{"facility":267,"status":7,"city":268,"state":269,"zip":270,"country":271,"contacts":272,"geoPoint":281},"Juravinski Hospital and Cancer Centre","Hamilton","Ontario","L8V 5C2","Canada",[273,277,279],{"name":274,"role":112,"phone":275,"email":276},"Elisabeth Lo","+1 905-387-9495","loe3@mcmaster.ca",{"name":278,"role":117},"Leyo Ruo, Dr.",{"name":280,"role":117},"George Markose, Dr.",{"lat":282,"lon":283},43.25011,-79.84963,{"facility":285,"status":7,"city":286,"state":269,"zip":287,"country":271,"contacts":288,"geoPoint":297},"The Ottawa Hospital","Ottawa","K1H 8L6",[289,293,295],{"name":290,"role":112,"phone":291,"email":292},"Zanna Vanterpool","+1 613-722-7000","zvanterpool@ohri.ca",{"name":294,"role":117},"Guillaume Martel, Dr.",{"name":296,"role":117},"Stephen Ryan, Dr.",{"lat":298,"lon":299},45.41117,-75.69812,{"facility":301,"status":7,"city":302,"state":303,"zip":304,"country":271,"contacts":305,"geoPoint":314},"McGill University Health Centre","Montreal","Quebec","H3G 1A4",[306,310,312],{"name":307,"role":112,"phone":308,"email":309},"Jennifer Kalil","+1 514-934-1934","Jennifer.kalil@mail.mcgill.ca",{"name":311,"role":117},"Peter Metrakos, Prof. Dr.",{"name":313,"role":117},"David Valenti, Dr.",{"lat":315,"lon":316},45.50884,-73.58781,{"facility":318,"status":7,"city":319,"state":320,"zip":321,"country":322,"contacts":323,"geoPoint":329},"University Hospital Aachen (Uniklinik RWTH Aachen)","Aachen","North Rhine-Westphalia","52074","Germany",[324,327],{"role":112,"phone":325,"email":326},"0241 80-0 oder 80-84444","info@ukaachen.de",{"name":328,"role":117},"Philipp Bruners, Prof. Dr.",{"lat":330,"lon":331},50.77664,6.08342,{"facility":333,"status":7,"city":334,"state":335,"zip":336,"country":322,"contacts":337,"geoPoint":345},"Klinikum Saarbrücken","Saarbrücken","Saarland","66119",[338,342,343],{"name":339,"role":112,"phone":340,"email":341},"Gregor Stavrou, Dr.","+49 681 9630","info@klinikum-saarbruecken.de",{"name":339,"role":117},{"name":344,"role":117},"Elmar Spüntrup, Dr.",{"lat":346,"lon":347},49.23262,7.00982,{"facility":349,"status":7,"city":350,"state":351,"zip":352,"country":322,"contacts":353,"geoPoint":360},"Universitätsklinikum Halle","Halle","Saxony-Anhalt","06120",[354,358],{"name":355,"role":112,"phone":356,"email":357},"Jörg Kleeff, Prof. Dr.","+49 345 5570","iuk@uk-halle.de",{"name":359,"role":117},"Jorg Kleeff, Prof. Dr.",{"lat":361,"lon":362},51.48158,11.97947,{"facility":364,"status":7,"city":365,"state":366,"zip":367,"country":368,"contacts":369,"geoPoint":376},"MUMC+","Maastricht","Limburg","6229HX","Netherlands",[370,374],{"name":371,"role":112,"phone":372,"email":373},"Fenna Van der Zijden, Dr.","+316 40911632","fenna.van.der.zijden@mumc.nl",{"name":375,"role":112},"Ronald Van Dam, Dr.",{"lat":377,"lon":378},50.84833,5.68889,{"facility":380,"status":7,"city":381,"state":382,"zip":383,"country":368,"contacts":384,"geoPoint":392},"Amsterdam UMC","Amsterdam","North Holland","1105 AZ",[385,388,390],{"name":386,"role":112,"email":387},"Fenna Van der Zijden","f.a.vanderzijden@amsterdamumc.nl",{"name":389,"role":117},"Joris Erdmann, Dr.",{"name":391,"role":117},"Ijsbrand Zijlstra, Dr.",{"lat":393,"lon":394},52.37403,4.88969,{"facility":396,"status":7,"city":397,"state":398,"zip":399,"country":368,"contacts":400,"geoPoint":409},"Universitair Medisch Centrum Groningen","Groningen","Provincie Groningen","9713 GZ",[401,405,407],{"name":402,"role":112,"phone":403,"email":404},"Mireille Zwijnen","050 361 6161","m.g.p.zwijnen@umcg.nl",{"name":406,"role":117},"Suomi Fouraschen, Dr.",{"name":408,"role":117},"Reinoud Bokkers, Dr.",{"lat":410,"lon":411},53.21917,6.56667,{"facility":413,"status":7,"city":414,"state":415,"zip":416,"country":368,"contacts":417,"geoPoint":425},"Leids Universitair Medisch Centrum","Leiden","South Holland","2333",[418,422,423],{"name":419,"role":112,"phone":420,"email":421},"Dries Braat, Dr.","071 526 9111","a.e.braat@lumc.nl",{"name":419,"role":117},{"name":424,"role":117},"Mark Burgmans, Dr.",{"lat":426,"lon":427},52.15833,4.49306,{"facility":429,"status":430,"city":431,"state":415,"zip":432,"country":368,"contacts":433,"geoPoint":442},"Erasmus MC","NOT_YET_RECRUITING","Rotterdam","3015 GD",[434,438,440],{"name":435,"role":112,"phone":436,"email":437},"Jessica Holster","(010) 704 0 704","j.holster@erasmusmc.nl",{"name":439,"role":117},"Bas Groot-Koerkamp, Prof. Dr.",{"name":441,"role":117},"Kay Pieterman, Dr.",{"lat":443,"lon":444},51.9225,4.47917,{"facility":446,"status":7,"city":447,"state":448,"zip":449,"country":450,"contacts":451,"geoPoint":457},"Auckland City Hospital","Grafton","Auckland","1023","New Zealand",[452,456],{"name":453,"role":112,"phone":454,"email":455},"Rukshan Fernando, Dr.","+64 9 367 0000","RukshanF@adhb.govt.nz",{"name":453,"role":117},{"lat":458,"lon":459},-36.86029,174.76566,{"facility":461,"status":7,"city":462,"state":462,"zip":463,"country":464,"contacts":465,"geoPoint":473},"Oslo University Hospital","Oslo","0424","Norway",[466,470,471],{"name":467,"role":112,"phone":468,"email":469},"Åsmund Fretland, Dr.","+47 22 11 80 80","fretland@gmail.com",{"name":467,"role":117},{"name":472,"role":117},"Ulrik Carling, Dr.",{"lat":474,"lon":475},59.91273,10.74609,{"facility":477,"status":7,"city":478,"state":479,"zip":480,"country":481,"contacts":482,"geoPoint":488},"Hospital Universitari Germans Trias i Pujol","Badalona","Barcelona","08916","Spain",[483,487],{"name":484,"role":112,"phone":485,"email":486},"Jordi Navinés López, Prof. Dr.","+34 934 65 12 00","uac.germanstrias@gencat.cat",{"name":484,"role":117},{"lat":489,"lon":490},41.45004,2.24741,{"facility":492,"status":7,"city":479,"state":479,"zip":493,"country":481,"contacts":494,"geoPoint":500},"Vall d'Hebron University Hospital","08035",[495,499],{"name":496,"role":112,"phone":497,"email":498},"Laura Vidal Piñeiro, Dr.","+34 934 89 30 00","web@vallhebron.cat",{"name":496,"role":117},{"lat":501,"lon":502},41.38879,2.15899,{"facility":504,"status":7,"city":505,"state":506,"zip":507,"country":508,"contacts":509,"geoPoint":518},"Karolinska University Hospital","Stockholm","Stockholm County","17176","Sweden",[510,514,516],{"name":511,"role":112,"phone":512,"email":513},"Soraya Bandeily","+46 8 123 700 00","soraya.bandeily@regionstockholm.se",{"name":515,"role":117},"Ernsto Sparrelid, Dr.",{"name":517,"role":117},"Martin Delle, Dr.",{"lat":519,"lon":520},59.32938,18.06871,{"facility":522,"status":7,"city":523,"state":524,"zip":525,"country":508,"contacts":526,"geoPoint":534},"University Hospital Linköping","Linköping","Östergötland County","581 85",[527,531,532],{"name":528,"role":112,"phone":529,"email":530},"Per Sandström, Dr.","+46 10 103 00 00","per.sandstrom@liu.se",{"name":528,"role":117},{"name":533,"role":117},"Aysun Erbahceci Salik, Dr.",{"lat":535,"lon":536},58.41086,15.62157,{"facility":538,"status":7,"city":539,"state":540,"zip":541,"country":542,"contacts":543,"geoPoint":549},"Klinik Hirslanden","Zurich","Canton of Zurich","8032","Switzerland",[544,548],{"name":545,"role":112,"phone":546,"email":547},"Erik Schadde, Dr.","+41 44 387 21 11","erik.schadde@hin.ch",{"name":545,"role":117},{"lat":550,"lon":551},47.36667,8.55,{"facility":553,"status":7,"city":554,"state":555,"zip":556,"country":557,"contacts":558,"geoPoint":570},"Aintree University Hospital","Liverpool","Merseyside","L9 7AL","United Kingdom",[559,563,566,568],{"name":560,"role":112,"phone":561,"email":562},"Jerry Mathew","+44 151 525 5980","Jerry.Mathew@liverpoolft.nhs.uk",{"name":564,"role":112,"phone":561,"email":565},"Giovanna Bretland","Giovanna.Bretland@liverpoolft.nhs.uk",{"name":567,"role":117},"Rafael Díaz-Nieto, Dr.",{"name":569,"role":117},"Rob Davis, Dr.",{"lat":571,"lon":572},53.41058,-2.97794,{"facility":574,"status":7,"city":575,"state":576,"zip":577,"country":557,"contacts":578,"geoPoint":584},"Newcastle upon Tyne Hospitals","Newcastle upon Tyne","North East England","NE7 7DN",[579,583],{"name":580,"role":112,"phone":581,"email":582},"Steve White, Prof. Dr.","+44 191 233 6161","steve.white@ncl.ac.uk",{"name":580,"role":117},{"lat":585,"lon":586},54.97328,-1.61396,{"facility":588,"status":7,"city":589,"state":590,"zip":591,"country":557,"contacts":592,"geoPoint":601},"Queen Elizabeth Hospital","Birmingham","West Midlands","B15 2GW",[593,597,599],{"name":594,"role":112,"phone":595,"email":596},"Diana Hull","+44 121 627 2000","Diana.Hull@uhb.nhs.uk",{"name":598,"role":117},"Robert Sutcliffe, Dr.",{"name":600,"role":117},"Homoyoon Mehrzad, Dr.",{"lat":602,"lon":603},52.48142,-1.89983,[605],{"name":371,"role":112,"phone":372,"email":373},[607],{"name":375,"affiliation":608,"role":117},"Maastricht Universitair Medisch Centrum",[610,614,617,620,623,626,629,632],{"pmid":611,"type":612,"citation":613},"41676779","BACKGROUND","James S, van der Leij C, van Dam RM, Detry O. Liver venous deprivation before major hepatectomy-promising but still a work in progress. Hepatobiliary Surg Nutr. 2026 Feb 1;15(1):10. doi: 10.21037\u002Fhbsn-2025-560. Epub 2026 Jan 12. No abstract available.",{"pmid":615,"type":612,"citation":616},"39078494","James S, Smits J, van der Velden AL, Simon SR, Korenblik R, Dewulf MJL, van Dam RM, van der Leij C; DRAGON Trials Collaborative. Invited Commentary on \"CIRSE Standards of Practice on Portal Vein Embolization and Double Vein Embolization\u002FLiver Venous Deprivation\". Cardiovasc Intervent Radiol. 2024 Sep;47(9):1311-1312. doi: 10.1007\u002Fs00270-024-03815-9. Epub 2024 Jul 29. No abstract available.",{"pmid":618,"type":612,"citation":619},"38662462","Korenblik R, Heil J, Smits J, James S, Olij B, Bechstein WO, Bemelmans MHA, Binkert CA, Breitenstein S, Williams M, Detry O, Dewulf MJL, Dili A, Grochola LF, Grote J, Heise D, Kalil JA, Metrakos P, Neumann UP, Pappas SG, Pennetta F, Schnitzbauer AA, Tasse JC, Winkens B, Olde Damink SWM, van der Leij C, Schadde E, van Dam RM; DRAGON trials collaborative. Liver regeneration after portal and hepatic vein embolization improves overall survival compared with portal vein embolization alone: mid-term survival analysis of the multicentre DRAGON 0 cohort. Br J Surg. 2024 Apr 3;111(4):znae087. doi: 10.1093\u002Fbjs\u002Fznae087.",{"pmid":621,"type":612,"citation":622},"36127520","Korenblik R, van der Leij C, van Dam RM. Reply to: Portal and Hepatic Vein Embolization to Accelerate Future Liver Remnant Hypertrophy-The Road Towards Level One Evidence. Cardiovasc Intervent Radiol. 2023 Jan;46(1):166-167. doi: 10.1007\u002Fs00270-022-03271-3. Epub 2022 Sep 20. No abstract available.",{"pmid":624,"type":612,"citation":625},"36437731","Korenblik R, van Zon JFJA, Olij B, Heil J, Dewulf MJL, Neumann UP, Olde Damink SWM, Binkert CA, Schadde E, van der Leij C, van Dam RM; DRAGON Trials Collaborative. Resectability of bilobar liver tumours after simultaneous portal and hepatic vein embolization versus portal vein embolization alone: meta-analysis. BJS Open. 2022 Nov 2;6(6):zrac141. doi: 10.1093\u002Fbjsopen\u002Fzrac141.",{"pmid":627,"type":612,"citation":628},"35790566","Korenblik R, Olij B, Aldrighetti LA, Hilal MA, Ahle M, Arslan B, van Baardewijk LJ, Baclija I, Bent C, Bertrand CL, Bjornsson B, de Boer MT, de Boer SW, Bokkers RPH, Rinkes IHMB, Breitenstein S, Bruijnen RCG, Bruners P, Buchler MW, Camacho JC, Cappelli A, Carling U, Chan BKY, Chang DH, Choi J, Font JC, Crawford M, Croagh D, Cugat E, Davis R, De Boo DW, De Cobelli F, De Wispelaere JF, van Delden OM, Delle M, Detry O, Diaz-Nieto R, Dili A, Erdmann JI, Fisher O, Fondevila C, Fretland A, Borobia FG, Gelabert A, Gerard L, Giuliante F, Gobardhan PD, Gomez F, Grunberger T, Grunhagen DJ, Guitart J, Hagendoorn J, Heil J, Heise D, Herrero E, Hess GF, Hoffmann MH, Iezzi R, Imani F, Nguyen J, Jovine E, Kalff JC, Kazemier G, Kingham TP, Kleeff J, Kollmar O, Leclercq WKG, Ben SL, Lucidi V, MacDonald A, Madoff DC, Manekeller S, Martel G, Mehrabi A, Mehrzad H, Meijerink MR, Menon K, Metrakos P, Meyer C, Moelker A, Modi S, Montanari N, Navines J, Neumann UP, Peddu P, Primrose JN, Qu X, Raptis D, Ratti F, Ridouani F, Rogan C, Ronellenfitsch U, Ryan S, Sallemi C, Moragues JS, Sandstrom P, Sarria L, Schnitzbauer A, Serenari M, Serrablo A, Smits MLJ, Sparrelid E, Spuntrup E, Stavrou GA, Sutcliffe RP, Tancredi I, Tasse JC, Udupa V, Valenti D, Fundora Y, Vogl TJ, Wang X, White SA, Wohlgemuth WA, Yu D, Zijlstra IAJ, Binkert CA, Bemelmans MHA, van der Leij C, Schadde E, van Dam RM. Dragon 1 Protocol Manuscript: Training, Accreditation, Implementation and Safety Evaluation of Portal and Hepatic Vein Embolization (PVE\u002FHVE) to Accelerate Future Liver Remnant (FLR) Hypertrophy. Cardiovasc Intervent Radiol. 2022 Sep;45(9):1391-1398. doi: 10.1007\u002Fs00270-022-03176-1. Epub 2022 Jul 5.",{"pmid":630,"type":612,"citation":631},"36680689","Chang X, Korenblik R, Olij B, Knapen RRMM, van der Leij C, Heise D, den Dulk M, Neumann UP, Schaap FG, van Dam RM, Olde Damink SWM. Influence of cholestasis on portal vein embolization-induced hypertrophy of the future liver remnant. Langenbecks Arch Surg. 2023 Jan 21;408(1):54. doi: 10.1007\u002Fs00423-023-02784-w.",{"pmid":633,"type":612,"citation":634},"33661306","Heil J, Korenblik R, Heid F, Bechstein WO, Bemelmans M, Binkert C, Bjornsson B, Breitenstein S, Detry O, Dili A, Dondelinger RF, Gerard L, Gimenez-Maurel T, Guiu B, Heise D, Hertl M, Kalil JA, Klein JJ, Lakoma A, Neumann UP, Olij B, Pappas SG, Sandstrom P, Schnitzbauer A, Serrablo A, Tasse J, Van der Leij C, Metrakos P, Van Dam R, Schadde E. Preoperative portal vein or portal and hepatic vein embolization: DRAGON collaborative group analysis. Br J Surg. 2021 Jul 23;108(7):834-842. doi: 10.1093\u002Fbjs\u002Fznaa149.",[],{"nct_id":4,"conditions":637,"biomarkers":642},[37,638,639,640,641],"Hilar Cholangiocarcinoma","Intrahepatic Cholangiocarcinoma","Liver Carcinoma","Metastatic Malignant Neoplasm in the Liver",[],{"nct_id":4,"found":644,"summary":645,"prompt_version":655},true,{"design":646,"status":647,"heading":648,"summary":649,"follow_up":650,"word_count":651,"commitments":652,"compensation":653,"drugs_mentioned":654},"This is an observational study, meaning researchers will collect information from patients. It plans to include about 350 participants.","completed","DRAGON Registry for Liver Cancer and Metastases","The DRAGON Registry is collecting information on patients with liver cancer or liver metastases (cancer that has spread to the liver) that cannot be removed by surgery right away. This registry looks at a procedure called combined portal and hepatic vein embolization (PVE\u002FHVE). This procedure helps the liver grow larger before surgery to remove the tumor. The study aims to understand how well PVE\u002FHVE works and if it is safe. Researchers will also look at how different patient characteristics affect the results. You may be able to join if you are 18 or older and have already had the PVE\u002FHVE procedure or a similar one. The main goals are to see if the tumor can be removed three weeks after the procedure and to track how long patients live over five years. The current recruitment status is unclear.","Participants will be followed from enrollment until five years after the procedure.",138,"Not specified in the trial record.","Not stated in the trial record.",[],"v2"]