[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT07720271":3,"trial-entities:NCT07720271":383,"trial-summary:NCT07720271":386},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":7,"overall_status":8,"completion_date":9,"status_verified_date":10,"last_update_date":11,"start_date":12,"sponsor_name":13,"lead_sponsor_class":14,"has_dmc":15,"brief_summary":16,"detailed_description":17,"conditions":18,"keywords":21,"study_type":22,"primary_purpose":23,"phases":24,"enrollment_info":26,"interventions":29,"primary_outcomes":39,"secondary_outcomes":44,"sex":51,"minimum_age":52,"maximum_age":17,"healthy_volunteers":15,"eligibility_criteria":53,"std_ages":62,"locations":65,"central_contacts":371,"overall_officials":377,"references":381,"see_also_links":382},"NCT07720271","NN9487-8023","AMAZE 9: A Research Study Investigating How Well Zenagamtide Tablets Help People With Excess Body Weight Lose Weight","Efficacy and Safety of Once-daily Oral Zenagamtide in Participants With Obesity (AMAZE 9)","NOT_YET_RECRUITING","2028-08-22","2026-07","2026-07-22","2026-09-01","Novo Nordisk A\u002FS","INDUSTRY",false,"The purpose of this clinical study is to find out if zenagamtide is safe and effective for treating people who have excess body weight. There are 2 study treatments in this study taken as oral tablets once a day. Participants will either get zenagamtide (the treatment being tested) or Placebo (treatment that has no active medicine in it). Which treatment participants get is decided by chance.",null,[19,20],"Overweight","Obesity",[],"INTERVENTIONAL","TREATMENT",[25],"PHASE3",{"count":27,"type":28},950,"ESTIMATED",[30,35],{"type":31,"name":32,"description":33,"armGroupLabels":34},"DRUG","zenagamtide","zenagamtide will be taken orally.",[32],{"type":31,"name":36,"description":37,"armGroupLabels":38},"Placebo","Placebo matched to zenagamtide will be taken orally.",[36],[40],{"measure":41,"description":42,"timeFrame":43},"Relative change in body weight","Measured as percentage (%) change in body weight.","From baseline (week 0) to (week 76)",[45,48],{"measure":46,"description":47,"timeFrame":43},"Change in waist circumference","Measured as centimetre (cm)",{"measure":49,"description":50,"timeFrame":43},"Change in systolic blood pressure (SBP)","Measured as millimetre of mercury (mmHg).","ALL","18 Years",{"inclusion":54,"exclusion":57,"raw_text":61},[55,56],"Male or female (sex at birth).","Age 18 and older (both inclusive) at time of signing the informed consent.",[58,59,60],"Glycated haemoglobin (HbA1c) more than or equal to (≥) 6.5% \\[48 millimoles per mole (mmol\u002Fmol)\\] as measured by the central laboratory at screening.","History of type 1 or type 2 diabetes mellitus as declared by the participant or reported in the medical records.","Treatment with glucagon-like peptide-1 (GLP-1) receptor agonists (RA), dual GLP-1\u002Fgastric inhibitory peptide (GIP) RAs (or any other GLP-1 based treatment) or amylin analogues before screening.","Inclusion Criteria:\n\n* Male or female (sex at birth).\n* Age 18 and older (both inclusive) at time of signing the informed consent.\n\nExclusion Criteria:\n\n* Glycated haemoglobin (HbA1c) more than or equal to (≥) 6.5% \\[48 millimoles per mole (mmol\u002Fmol)\\] as measured by the central laboratory at screening.\n* History of type 1 or type 2 diabetes mellitus as declared by the participant or reported in the medical records.\n* Treatment with glucagon-like 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receive either zenagamtide or a placebo. It aims to enroll about 950 participants.","completed","AMAZE 9: Zenagamtide Tablets for Excess Body Weight","This study, called AMAZE 9, is investigating if zenagamtide tablets are a safe and effective way to help people with excess body weight lose weight. You would take an oral tablet once a day. Participants will either receive zenagamtide or a placebo (a tablet with no active medicine). Which treatment you receive is decided by chance. The main goal is to see how much body weight changes over 76 weeks. To join, you must be 18 years or older and have a glycated hemoglobin (HbA1c) level less than 6.5%. The study is currently recruiting about 950 participants.","The study measures body weight changes from the start of the study (week 0) up to week 76.",97,"You would take an oral tablet once a day. The primary endpoint for measuring body weight change is from baseline (week 0) to week 76.","Not stated in the trial record.",[32,36],"v2"]