[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"trial:NCT07721220":3,"trial-entities:NCT07721220":125,"trial-summary:NCT07721220":132},{"id":4,"nct_id":4,"org_study_id":5,"brief_title":6,"official_title":7,"overall_status":8,"completion_date":9,"status_verified_date":9,"last_update_date":10,"start_date":11,"sponsor_name":12,"lead_sponsor_class":13,"has_dmc":14,"brief_summary":15,"detailed_description":16,"conditions":17,"keywords":29,"study_type":33,"primary_purpose":34,"phases":35,"enrollment_info":37,"interventions":40,"primary_outcomes":61,"secondary_outcomes":66,"sex":71,"minimum_age":72,"maximum_age":73,"healthy_volunteers":74,"eligibility_criteria":75,"std_ages":97,"locations":99,"central_contacts":117,"overall_officials":120,"references":123,"see_also_links":124},"NCT07721220","IRB-FY2026-110","Acute Effects of Neurodynamics on Strength and Endurance in Athletes","Acute Effects of Neurodynamics on Strength and Endurance in Athletes: A Randomized Control Trial","RECRUITING","2026-07","2026-07-22","2026-06-15","High Point University","OTHER",false,"This study explores the acute effects of neurodynamics, an intervention commonly used by physical therapist to improve nerve mobility and decrease pain, on the strength and muscular endurance in the athletic population. This study aims to find if these interventions can maintain or promote strength and endurance in the hamstrings. The studies results will help physical therapist better prescribe exercise and hands-on treatment for hamstring and sciatic nerve related conditions and injuries.",null,[18,19,20,21,22,23,24,25,26,27,28],"Sciatic Leg Pain","Hamstring Muscle Tightness","Hamstring Muscle Strain","Hamstring Muscle Strength","Hamstring Injuries","Hamstring Injury Prevention","Hamstring Rupture","Sciatic Nerve Injury","Sciatic Radiculopathy","Lumbar Disc Herniation With Radiculopathy","Lumbar Disc Herniation",[30,31,32],"hamstring","sciatic nerve","athlete","INTERVENTIONAL","TREATMENT",[36],"NA",{"count":38,"type":39},45,"ESTIMATED",[41,46,51,56],{"type":13,"name":42,"description":43,"armGroupLabels":44},"Sciatic Slider","Mobility of a nerve, by placing tension on one end of the nerve and slacking (removing) tension off the other side of the nerve, through a full range of motion.",[45],"Sliders",{"type":13,"name":47,"description":48,"armGroupLabels":49},"Sciatic Tensioner","Loading the nerve, by placing tension on both ends of the nerve, isometrically at end range of motion.",[50],"Tensioners",{"type":13,"name":52,"description":53,"armGroupLabels":54},"Mechanically loaded neurodynamic sciatic floss","Placing tension on one end of the nerve while taking the tension off the other end, under external load of an elastic resistance band.",[55],"Mechanically Loaded Neurodynamics",{"type":57,"name":58,"description":59,"armGroupLabels":60},"DEVICE","Elastic Resistance Band","Elastic resistance band was used to provide submaximal resistance during the mechanically loaded neurodynamic intervention.",[55],[62],{"measure":63,"description":64,"timeFrame":65},"Isometric Strength","Isometric strength of the hamstrings in knee flexion.","From initial strength and endurance test, to the post intervention strength and endurance test, assessed during a single study visit, assessed up to 30 minutes.",[67],{"measure":68,"description":69,"timeFrame":70},"Endurance Ratio (isokinetic)","Endurance ratio of knee flexion, measured isokinetically.","From initial endurance test to post intervention endurance test, during a single study visit, assessed up to 30 minutes.","ALL","18 Years","30 Years",true,{"inclusion":76,"exclusion":86,"raw_text":96},[77,78,79,80,81,82,83,84,85],"Participants must be between 18 and 30 years of age.","Must be able to read, understand, and provide informed consent, in English.","Must be currently participating in an organized sport (e.g. collegiate, club, or competitive recreational level) or engaging in structured resistance training and athletic conditioning for recreational sports events (e.g 5k, marathon, Crossfit, Hyrox, etc).","Medically stable with no known contraindications to physical exertion.","Cleared for participation in strength or maximal-effort isometric testing.","Be able to perform lower extremity isometric testing without pain that limits maximal effort.","Must have 2 lower extremities capable to producing full range knee flexion and extension range of motion.","No medical condition that significantly alters lower extremity neuromuscular performance.","No history of lower extremity surgery in the past 12 months.",[87,88,89,90,91,92,93,94,95],"Individuals younger than 18 or older than 30.","Acute lower extremity injury in the last 12 weeks.","Lower extremity surgery within the last 12 months.","Pain in either lower extremity that would limit maximal physical exertion.","History of neurological disorders, including but not limited to: Neuropathy, Stoke, MS, Parkinson's Disease, etc.","Use of medications that significantly impact neuromuscular performance, strength or fatigue.","No supplementation that affects neuromuscular performance, strength, or fatigue.","Unable to read and understand English.","Not in a vulnerable population: Pregnant, mentally or physically challenged, cognitively impaired.","Inclusion Criteria:\n\n* Participants must be between 18 and 30 years of age.\n* Must be able to read, understand, and provide informed consent, in English.\n* Must be currently participating in an organized sport (e.g. collegiate, club, or competitive recreational level) or engaging in structured resistance training and athletic conditioning for recreational sports events (e.g 5k, marathon, Crossfit, Hyrox, etc).\n* Medically stable with no known contraindications to physical exertion.\n* Cleared for participation in strength or maximal-effort isometric testing.\n* Be able to perform lower extremity isometric testing without pain that limits maximal effort.\n* Must have 2 lower extremities capable to producing full range knee flexion and extension range of motion.\n* No medical condition that significantly alters lower extremity neuromuscular performance.\n* No history of lower extremity surgery in the past 12 months.\n\nExclusion Criteria:\n\n* Individuals younger than 18 or older than 30.\n* Acute lower extremity injury in the last 12 weeks.\n* Lower extremity surgery within the last 12 months.\n* Pain in either lower extremity that would limit maximal physical exertion.\n* History of neurological disorders, including but not limited to: Neuropathy, Stoke, MS, Parkinson's Disease, etc.\n* Use of medications that significantly impact neuromuscular performance, strength or fatigue.\n* No supplementation that affects neuromuscular performance, strength, or fatigue.\n* Unable to read and understand English.\n* Not in a vulnerable population: Pregnant, mentally or physically challenged, cognitively impaired.",[98],"ADULT",[100],{"facility":12,"status":8,"city":101,"state":102,"zip":103,"country":104,"contacts":105,"geoPoint":114},"High Point","North Carolina","27268","United States",[106,111],{"name":107,"role":108,"phone":109,"email":110},"Dr. Tommy Wyatt, DPT","CONTACT","856-381-6652","twyatt2@highpoint.edu",{"name":112,"role":113},"Tommy Wyatt, DPT","PRINCIPAL_INVESTIGATOR",{"lat":115,"lon":116},35.95569,-80.00532,[118],{"name":119,"role":108,"phone":109,"email":110},"Dr. Tommy Wyat, DPT",[121],{"name":112,"affiliation":122,"role":113},"High PointUniversity",[],[],{"nct_id":4,"conditions":126,"biomarkers":131},[127,128,129,130],"Hamstring injury","Injury of sciatic nerve","Prolapsed lumbar intervertebral disc","Toxic radiculopathy",[],{"nct_id":4,"found":74,"summary":133,"prompt_version":143},{"design":134,"status":135,"heading":136,"summary":137,"follow_up":138,"word_count":139,"commitments":140,"compensation":141,"drugs_mentioned":142},"This is an interventional study planning to enroll 45 participants. The phase of the study is not specified.","completed","Study on Neurodynamics for Hamstring Strength and Endurance in Athletes","This study is looking at how different neurodynamic techniques, like Sciatic Slider, Sciatic Tensioner, and Mechanically loaded neurodynamic sciatic floss, affect hamstring strength and endurance in athletes. These techniques are often used by physical therapists to improve nerve movement and reduce pain. The study wants to see if these interventions can help maintain or improve hamstring strength and endurance. You might be able to join if you are an athlete between 18 and 30 years old. The main goal is to measure changes in isometric strength shortly after the intervention. The study status is currently unclear.","Participants are assessed up to 30 minutes after the intervention during a single study visit.",96,"Participants will undergo an initial strength and endurance test, receive an intervention, and then have a post-intervention strength and endurance test, all within a single study visit lasting up to 30 minutes.","Not stated in the trial record.",[42,47,52],"v2"]