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Understanding Thyroid Function Disorders

This observational study aims to better understand thyroid function disorders like hyperthyroidism (overactive thyroid), hypothyroidism (underactive thyroid), and Graves' Disease. Researchers will study the natural progression, symptoms, and genetic factors related to these conditions. You might be eligible if you are between 6 months and 98 years old and have a known or suspected thyroid abnormality. The study will collect clinical data and blood/tissue samples during your standard medical care, which may include physical exams, blood tests, and imaging scans. The main goal is to learn more about the causes of these disorders and how current treatments affect patients over time. This study is ongoing and is not testing a specific drug or intervention.

Study design
This is an observational study, meaning researchers will gather information about your condition during your regular medical care. It aims to enroll about 2500 participants.
What's involved
You would undergo routine history and physical examinations, standard endocrine blood and urine tests, and various scans (like nuclear medicine scans or X-rays) as part of your regular care. Blood and tissue samples may also be taken for research.
Compensation
Not stated in the trial record.
Follow-up
The evaluation of thyroid disorders is measured on an ongoing basis.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT00001159

Natural History of Thyroid Function Disorders

Recruiting
Not specifiedAges 6–98Observational
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
~2,500 participants
Updated 2026-08-28 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
evaluation of thyroid disorders
Measured over ongoing

Conditions

Hyperthyroidism
Hypothyroidism
Grave's Disease

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Where it's being run

1 sites across 1 states
Maryland1

Study leadership

  • Sriram M Gubbi, M.D. · PRINCIPAL_INVESTIGATOR · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Who to contact

Padmasree Veeraraghavan, R.N.
[email protected]
(301) 451-7710
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Non-thyroidal illness
Abnormalities of serum TH binding proteins leading to euthyroid hyperthyroxinemia or hypotriiodothyronemia.
Genetic deficiency of thyroxine-binding globulin (TBG).
Antibodies to mouse immunoglobulins leading to an artifactual elevation in the TSH ultrasensitive ("3rd generation") assay which may mimic "inappropriate" secretion of TSH.

What this trial measures

  • evaluation of thyroid disordersongoing

    Patients undergo routine history and physical examination, standard endocrine blood and urine tests, a standard TRH test, thyroid nuclear medicine scans, thyroidal radioiodine (RAI) or technetium (99mTc) uptake measurements, as well as X-ray, computed tomography (CT) or magnetic resonance imaging (MRI) studies or other standard diagnostic procedures, as clinically indicated.