This observational study aims to understand the genetic causes and characteristics of diseases that cause repeated fevers, such as Familial Mediterranean Fever (FMF), TRAPS, and hyper-IgD syndrome. Researchers are looking for people with known or suspected autoinflammatory diseases, their family members, and healthy volunteers. The study involves medical history, physical exams, blood and urine tests, and DNA collection. Some participants may also have X-rays or specialist consultations. The main goal is to find genetic differences that make people susceptible to these inflammatory conditions. This study is currently unclear on its recruitment status and does not involve any specific interventions or drugs.

Study design

This is an observational study planning to enroll up to 5000 participants. It is designed to explore the natural history of these conditions.

What's involved

Participants will undergo a medical and family history, physical examination, blood and urine tests. Additional tests like X-rays, specialist consultations, and DNA sample collection may also occur.

Compensation

Not stated in the trial record.

Follow-up

Genetic linkage in autoinflammatory disease will be measured annually. Other follow-up details are not specified.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.