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Understanding Post-Treatment Lyme Disease Syndrome

This study aims to understand why some people continue to have symptoms after being treated for Lyme disease. Researchers want to find out if the Lyme bacteria, Borrelia burgdorferi, is still present and causing these ongoing symptoms. By gathering detailed information from people with post-treatment Lyme disease syndrome (PTLDS) and different control groups, this study hopes to create better ways to diagnose Lyme disease and develop new treatments in the future. You might be able to join if you are 13 years or older and suspected of having Lyme disease, or if you fit into categories like chronic Lyme disease, chronic Lyme arthritis, or certain control groups.

Study design
This is an observational study involving up to 700 participants. It is designed to assemble and follow a well-characterized group of patients and controls.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for the duration of the study.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT00001539

A Comprehensive Clinical, Microbiological and Immunological Assessment of Patients With Suspected Post Treatment Lyme Disease Syndrome and Selected Control Populations

Recruiting
Not specifiedAges 13–99Observational
National Institute of Allergy and Infectious Diseases (NIAID)
~700 participants
Updated 2026-08-31 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Assemble and follow a well-characterized cohort of patients with post-treatment Lyme disease syndrome and relevant controls
Measured over duration of the study

Conditions

Lyme Disease

Explore related trials

Borrelia Burgdorferi InfectionLyme ArthritisMultiple SclerosisB. burgdorferiSFTPA1 wt Allele

NCT00001539

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • National Institutes of Health Clinical Center

    Bethesda, Marylandstudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Adriana R Marques, M.D. · PRINCIPAL_INVESTIGATOR · National Institute of Allergy and Infectious Diseases (NIAID)

Who to contact

Ashley M Thomas
[email protected]
(240) 656-5458
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

What this trial measures

  • Assemble and follow a well-characterized cohort of patients with post-treatment Lyme disease syndrome and relevant controlsduration of the study

    This protocol serves as the basis for multiple parallel lines of investigation in different aspects of Lyme disease and PTLDS. The formation of the cohort and follow up are the main outcomes.