Understanding Pituitary Tumors and Related Conditions

This study is looking into tumors that affect the pituitary gland (a small gland at the base of your brain) and related brain disorders. Researchers want to understand the genetic causes of these tumors, including conditions like panhypopituitarism (when the pituitary gland doesn't make enough hormones), gigantism/acromegaly (too much growth hormone), prolactinoma (a tumor that makes too much prolactin), and Cushing disease (too much cortisol). You might have tissue samples collected and undergo an MRI scan. The main goal is to perform genetic testing on these samples to learn more about how these tumors develop. This study also helps train doctors and develop future research on these conditions.

Study design
This is an observational study aiming to enroll 2000 participants aged 2 to 70 years old. It is not specified if it's a specific phase of research.
What's involved
You would need to be willing to follow all study procedures and be available for the duration of the study. This may include tissue specimen collection and MRI scans.
Compensation
Not stated in the trial record.
Follow-up
Molecular genetic testing is an ongoing endpoint, but specific follow-up duration is not specified.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT00001595

An Investigation of Pituitary Tumors and Related Hypothalmic Disorders

Recruiting
Not specifiedAges 2–70Observational
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
~2,000 participants
Updated 2026-08-17 on ClinicalTrials.gov
What's tested:Tissue specimen collectionMRI

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Molecular genetic testing, whole exome sequencing
Measured over ongoing
Panhypopituitarism
Gigantism/Acromegaly
Prolactinoma
Cushing Disease
1 sites across 1 states
Maryland1
  • Deborah P Merke, M.D. · PRINCIPAL_INVESTIGATOR · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

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  • Molecular genetic testing, whole exome sequencingongoing

    To collect peripheral blood samples and tumor tissues and examine the molecular genetics of the specimens, in an effort to elucidate developmental pathways leading to pituitary gland oncogenesis and/or other defects.