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Observational Study on the Natural History of Stroke

This study aims to better understand stroke and related conditions like Transient Ischemic Attacks (TIAs), which are temporary stroke-like symptoms. Researchers are observing how these conditions develop over time. They will collect information from patients to create a registry and identify patterns in stroke and TIA. This information will help researchers develop new ideas for future studies. You may be eligible if you are 18 or older and have experienced or are at risk of a stroke or TIA, and are seen at Suburban Hospital's emergency department or inpatient units.

Study design
This is an observational study with a planned enrollment of 4000 participants. It is not testing a specific intervention or drug.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The study will look at brain imaging results at post-acute, 24 hours, 5 days/discharge, and 30 days after the initial event.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT00009243

Natural History of Stroke: Cause and Development

Recruiting
Not specifiedAges 18+Observational
National Institute of Neurological Disorders and Stroke (NINDS)
~4,000 participants
Updated 2026-08-27 on ClinicalTrials.gov

At a glance

Recruiting sites
3 of 3 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Prevalence and type of abnormalities seen on neuroimaging as a function of time from acute insult
Measured over Post-acute, 24 hours, 5 days/discharge, 30 days

Conditions

Brain Disease
Ischemic Attack, Transient
Cerebrovascular Accident
Cerebrovascular Disorder
Vascular Diseases

Explore related trials

Cerebrovascular DisorderStrokeTransient Ischemic Attack

Where it's being run

3 sites across 2 states
Maryland2
District of Columbia1

Study leadership

  • Lawrence L Latour, Ph.D. · PRINCIPAL_INVESTIGATOR · National Institute of Neurological Disorders and Stroke (NINDS)

Who to contact

Nicole L Peterkin
[email protected]
(301) 435-2395
Email the study team

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Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

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Eligibility criteria

Exclusion

Central nervous system aneurysm clips
Implanted neural stimulator
Implanted cardiac pacemaker or defibrillator
Cochlear implant
Ocular foreign body (e.g. metal shavings)
Insulin pump
Metal shrapnel or bullet
Any implanted device that is incompatible with MRI

What this trial measures

  • Prevalence and type of abnormalities seen on neuroimaging as a function of time from acute insultPost-acute, 24 hours, 5 days/discharge, 30 days

    Neuroimaging abnormalities, such as:-Imaging positive for acute ischemic cerebral vascular syndrome ( AICS positive )-Presence of a lesion on diffusion, perfusion, and mismatch between the two-Evidence of a vascular occlusion on MR angiography-Evidence of a thrombus or hemorrhage on T2\* GRE imaging-Blood-brain barrier disruption as evidence by "HARM"-The evolution of these markers with time and treatment