Follow-up Study for High-Risk Infants

This is an observational study, meaning there are no interventions or treatments being tested. It's a follow-up study for infants born very prematurely (before 27 weeks gestational age) at specific Neonatal Research Network (NRN) centers. The study aims to understand how different factors during pregnancy and after birth might affect a baby's brain development. Researchers collect information on development of motor skills, thinking skills, language, and behavior when the children are between 18 and 26 months corrected age (this means their age adjusted for how premature they were). The goal is to identify potential risk factors and understand the long-term outcomes for these high-risk infants. The study is currently collecting data for a long-term registry.

Study design
This is an observational study with no intervention, planning to include 68,000 participants. It is a multi-center cohort study.
What's involved
Participants will undergo neurodevelopmental, neurosensory, and functional assessments at 22-26 months corrected age (or 18-22 months corrected age for infants born before July 1, 2012).
Compensation
Not stated in the trial record.
Follow-up
Data is being collected for a longitudinal database, currently funded through March 31, 2016.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT00009633

Follow-up Visit of High Risk Infants

Recruiting
Not specifiedAges 18–26Observational
NICHD Neonatal Research Network
~68,000 participants
Updated 2026-07-01 on ClinicalTrials.gov
What's tested:No Intervention

At a glance

Recruiting sites
16 of 31 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
To maintain a registry of baseline and outcome data for VLBW infants with data collected in a uniform manner
Measured over Longitudinal database currently funded through 3/31/2016
Infant, Newborn
Infant, Low Birth Weight
Infant, Small for Gestational Age
Infant, Premature

NCT00009633

Where you'd take part

This study runs at 31 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Case Western Reserve University, Rainbow Babies and Children's Hospital

    Cleveland, Ohiono site contact published

    Recruiting

  • Children's Mercy Hospital

    Kansas City, Missourino site contact published

    Recruiting

  • Cincinnati Children's Medical Center

    Cincinnati, Ohiono site contact published

    Recruiting

  • Duke University

    Durham, North Carolinano site contact published

    Recruiting

  • Emory University

    Atlanta, Georgiano site contact published

    Recruiting

  • Indiana University

    Indianapolis, Indianano site contact published

    Recruiting

  • Northwestern Lurie Children's Hospital of Chicago

    Chicago, Illinoisno site contact published

    Not yet recruiting

  • Sharp Mary Birch Hospital for Women & Newborns

    San Diego, Californiano site contact published

    Not yet recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

  • Abbot R. Laptook, MD · PRINCIPAL_INVESTIGATOR · Brown University, Women & Infants Hospital of Rhode Island
  • Michele C. Walsh, MD MS · PRINCIPAL_INVESTIGATOR · Case Western Reserve University, Rainbow Babies and Children's Hospital
  • C. Michael Cotten, MD, MHS · PRINCIPAL_INVESTIGATOR · Duke University
  • David P. Carlton, MD · PRINCIPAL_INVESTIGATOR · Emory University
  • Greg M. Sokol, MD · PRINCIPAL_INVESTIGATOR · Indiana University
  • Abhik Das, PhD · PRINCIPAL_INVESTIGATOR · RTI International
  • Krisa P. Van Meurs, MD · PRINCIPAL_INVESTIGATOR · Stanford University
  • Brenda B. Poindexter, MD · PRINCIPAL_INVESTIGATOR · Children's Hospital Medical Center, Cincinnati
  • Waldemar A. Carlo, MD · PRINCIPAL_INVESTIGATOR · University of Alabama at Birmingham
  • Edward F. Bell, MD · PRINCIPAL_INVESTIGATOR · University of Iowa
  • Kristi L. Watterberg, MD · PRINCIPAL_INVESTIGATOR · University of New Mexico
  • Myra H. Wyckoff, MD · PRINCIPAL_INVESTIGATOR · University of Texas, Southwestern Medical Center at Dallas
  • Jon E Tyson, MD, MPH · PRINCIPAL_INVESTIGATOR · The University of Texas Health Science Center, Houston
  • Bradley A. Yoder, MD · PRINCIPAL_INVESTIGATOR · University of Utah
  • Seetha Shankaran, MD · PRINCIPAL_INVESTIGATOR · Wayne State University
  • William E. Truog, MD · PRINCIPAL_INVESTIGATOR · Children's Mercy Hospital Kansas City
  • Pablo J. Sanchez, MD · PRINCIPAL_INVESTIGATOR · Research Institute at Nationwide Children's Hospital
  • Uday Devaskar, MD · PRINCIPAL_INVESTIGATOR · University of California, Los Angeles
  • Carl T D'Angio, MD · PRINCIPAL_INVESTIGATOR · University of Rochester
  • Eric C Eichenwald, MD · PRINCIPAL_INVESTIGATOR · University of Pennsylvania

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  • To maintain a registry of baseline and outcome data for VLBW infants with data collected in a uniform mannerLongitudinal database currently funded through 3/31/2016