This observational study aims to better understand severe mood dysregulation in children and adolescents aged 7-17. Researchers are looking at children and teens who show chronic anger, sadness, or irritability, along with symptoms like trouble sleeping, being easily distracted, or having extreme temper tantrums. The study will describe their moods and behaviors and use special tests and brain imaging to learn about brain changes connected to these symptoms. One intervention mentioned is Lithium, a medication often used for mood disorders. The study hopes to find differences in clinical, behavioral, genetic, and brain-related factors, and how irritability is linked to these factors over 20 years. This study is currently unclear on its recruitment status.

Study design

This is an observational study with a planned enrollment of 2350 participants. It is not testing a specific treatment, but rather observing participants over time.

What's involved

Not specified in the trial record.

Compensation

Not stated in the trial record.

Follow-up

Participants will be followed for 20 years to examine various clinical, behavioral, genetic, neuroanatomical, and neurophysiological variables.

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