Back to search results

MRI Study of Musculoskeletal Function

This observational study uses magnetic resonance imaging (MRI) and ultrasound to understand how your muscles, tendons, and bones work together to create movement. The goal is to develop better ways to diagnose and treat problems with movement. Researchers will measure how tissues like bone and muscle move during knee bending and straightening. You may be able to join if you are between 5 and 95 years old, with or without joint problems. If you have joint problems, you cannot have serious injury, previous surgery, or extreme pain in the joint being studied. The study aims to create detailed 3D images of moving joints to understand how they function.

Study design
This is an observational study with a planned enrollment of 750 participants. It is not a treatment study, but rather focuses on understanding musculoskeletal function.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Dynamic MRI measures will be taken at the end of the study.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT00051857

MRI Study of Musculoskeletal Function

Recruiting
Not specifiedAges 5–95Observational
National Institutes of Health Clinical Center (CC)
~750 participants
Updated 2026-08-31 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Dynamic MRI measures of in vivo tissue velocity, bone and muscle, during dynamic tasks of knee flexion/extension
Measured over End of study

Conditions

Abnormalities
Imaging
Patellofemoral Pain Syndrome

Explore related trials

Musculoskeletal System PathologyPatellofemoral stress syndrome

NCT00051857

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • National Institutes of Health Clinical Center

    Bethesda, Marylandno site contact published

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Frances T Gavelli, Ph.D. · PRINCIPAL_INVESTIGATOR · National Institutes of Health Clinical Center (CC)

Who to contact

Frances T Gavelli, Ph.D.
[email protected]
(301) 451-7585
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

Want this trial checked against your situation?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Must be between the ages of 5-95 years.
Minors \< 18 years of age, they must be capable of providing assent (verbal or written) with parental or legal guardian permissions obtained.
Adults 18 \>= years of age, they must be able to provide informed consent.
Have the presence of a bone, muscle, soft tissue, connective tissue injury, impairment or related muscular skeletal system pathology.
Ability to have an MRI Scan.
Must be between the ages of 5-95 years.
Minors \< 18 years of age, they must be capable of providing assent (verbal or written) with parental or legal guardian permissions obtained.
Adults 18 \>= years of age, they must be able to provide informed consent.
Ability to have an MRI Scan.

Exclusion

For the MR imaging portion of this study, all participants must complete the NIH Diagnostic Radiology screening questionnaire. If any potential contraindication is found, either the volunteer s doctor (with knowledge of the potential contraindication) or the radiology department at the NIH will be contacted to determine if the potential contraindication would exclude them from the specific MR scans being proposed.
Any relevant medical problems
Clinical signs of an impairment in the joint/limb being studied.
Any serious injury to the joint/limb being studied, previous surgery on the joint/limb being studied or extreme pain at the joint/limb being studied.
Neurologic Pathology affecting the muscular skeletal system
For the MR imaging portion of this study, all participants must complete the NIH Diagnostic Radiology screening questionnaire. If any potential contraindication is found, either the volunteer s doctor (with knowledge of the potential contraindication) or the radiology department at the NIH will be contacted to determine if the potential contraindication would exclude them from the specific MR scans being proposed.

What this trial measures

  • Dynamic MRI measures of in vivo tissue velocity, bone and muscle, during dynamic tasks of knee flexion/extensionEnd of study

    MRI techniques to non-invasively measure the 3D in vivo musculoskeletal kinematics, bone shapes, and muscle-tendon lengths in the joints of normal volunteers and healthy volunteers with specific joint impairments.