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Observational Study of Autoinflammatory Diseases and Juvenile Dermatomyositis

This study is looking at autoinflammatory diseases, including Juvenile Dermatomyositis (JDM), CANDLE, and SAVI, to better understand how they develop and what happens to people with these conditions over time. Researchers want to learn more about the clinical features, genetics, and immune system changes in people with these diseases. They are observing patients to identify what causes these conditions. You might be able to join if you are 2 years or older and have a confirmed diagnosis or meet the clinical criteria for JDM, CANDLE, SAVI, or other suspected autoinflammatory diseases. The main goal is to identify what causes these diseases, which will be assessed at each visit.

Study design
This is an observational study planning to enroll up to 5000 participants. It is not testing a specific treatment, but rather observing the natural course of the diseases.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The study aims to determine long-term outcomes and identify disease pathogenesis, which will be measured at each visit.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT00059748

Studies of the Natural History, Pathogenesis, and Outcome of Autoinflammatory Diseases Including Juvenile Dermatomyositis

Completed
Not specifiedAges 2+Observational
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
~757 participants
Updated 2026-08-27 on ClinicalTrials.gov

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Identification of disease pathogenesis
Measured over each visit

Conditions

Autoinflammatory Disease
Juvenile Dermatomyositis

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Where it's being run

1 sites across 1 states
Maryland1

Study leadership

  • Hanna Kim, M.D. · PRINCIPAL_INVESTIGATOR · National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Patients with CANDLE, SAVI, and JDM who are mutation positive for the disease or fulfill clinical criteria of the disease.
Patients who fulfill criteria for definite or probable JDM
Patients with other suspected autoinflammatory diseases
There is:
2 years old or older
Patients or their legal guardians need to be able and willing to give informed consent and a pediatric patient needs to be willing to assent to the protocol whenever possible.

Exclusion

Active malignancy or any medical condition that in the opinion of the investigator would warrant exclusion
Inability to return for follow up visits
Pregnancy
Adults without the capacity to consent

What this trial measures

  • Identification of disease pathogenesiseach visit

    Clinical, immunological, genetic and endocrinological characteristics of the disease