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Urinary Vitamin C Loss in Diabetic Subjects

This observational study is looking into how vitamin C levels are affected in people with diabetes compared to those without. Researchers want to understand if people with diabetes have lower vitamin C in their blood because their bodies lose more of it through urine. They will measure vitamin C levels in blood (plasma, neutrophils, and red blood cells) and urine at the end of the study. This study is open to adults aged 18 to 65, including both men and women, who either have Type 1 or Type 2 diabetes, or do not have diabetes. The study aims to enroll 5000 participants. The current recruitment status is unclear.

Study design
This is an observational study involving 5000 participants, comparing individuals with and without diabetes.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Vitamin C concentrations will be measured at the end of the study.

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NCT00071526

Urinary Vitamin C Loss in Diabetic Subjects

Recruiting
Not specifiedAges 18–65Observational
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
~5,000 participants
Updated 2026-08-31 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Plasma, neutrophil and RBC Vitamin C concentrates
Measured over end of study

Conditions

Diabetes

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Where it's being run

1 sites across 1 states
Maryland1

Study leadership

  • Ifechukwude C Ebenuwa, M.D. · PRINCIPAL_INVESTIGATOR · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Who to contact

Razi S Berman, C.R.N.P.
[email protected]
(301) 827-5757
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Eligibility criteria

Inclusion

Aged 18-65 years.
Either:
Have no diagnosis of diabetes: "nondiabetic controls", or
Have a diagnosis in their medical history of either Type 1 or Type 2 diabetes

Exclusion

Unable or unwilling to provide a signed and dated informed consent form
Unable or unwilling to comply with study procedures and lifestyle considerations
significant organ malfunction leading to clinical instability including liver disease, pulmonary disease, ischemic heart disease, heart failure, stroke, peripheral vascular disease, and anemia at investigator discretion
other serious or chronic illness; history of serious or chronic illness; coronary artery disease, or peripheral vascular disease resulting in clinical instability
pregnancy or lactation
presence of other conditions which, in the judgment of the investigators, can influence vitamin C metabolism or vitamin C renal handling

What this trial measures

  • Plasma, neutrophil and RBC Vitamin C concentratesend of study

    Measurements of plasma, neutrophil and red blood cell vitamin c concentrations in diabetic subjects as compared to healthy controls.