Collection of Data and Samples From Healthy Donors

This study is collecting blood, urine, sputum, stool, cerebrospinal fluid (fluid around the brain and spinal cord), skin, and bone marrow samples from healthy volunteers. Researchers need these samples to compare them with samples from patients who have a condition called eosinophilia (increased numbers of white blood cells called eosinophils) or parasitic diseases. This comparison helps them investigate these diseases. Some samples will be used for genetic testing or future research. The study aims to provide a way to collect these samples for in vitro (test tube) studies. You may be eligible if you are a healthy male or female between 18 and 85 years old. The study is currently unclear on its recruitment status.

Study design: This is an observational study planning to enroll up to 150 healthy volunteers. It is not testing any specific intervention.
What's involved: You would donate blood, body fluids, and/or tissue samples, and may undergo procedures like infrared thermography or an esophageal string test. The study will last about 10 years.
Compensation: Volunteers will be compensated according to an established schedule based on the duration and discomfort of the donation.
Follow-up: The primary endpoint is measured at 50 years, suggesting a very long-term collection or use of samples.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

Collection of Data and Samples From Healthy Donors for Use in Translational Research

Recruiting

Not specifiedAges 18–85Observational

National Institute of Allergy and Infectious Diseases (NIAID)

~150 participants

Updated 2026-09-01 on ClinicalTrials.gov

At a glance

Recruiting sites

1 of 1 listed site is recruiting right now

RecruitingSuspended, closed, or not yet open

What they're measuring

- To provide an IRB-approved mechanism for the collection of peripheral blood, urine, sputum, stool, cerebrospinal fluid, skin biopsy and bone marrow samples from paid, volunteer donors for use in in vitro studies.

Measured over 50 years

Conditions

Healthy Volunteer

Where it's being run

1 sites across 1 states

Maryland1

Study leadership

Amy D Klion, M.D. · PRINCIPAL_INVESTIGATOR · National Institute of Allergy and Infectious Diseases (NIAID)

Who to contact

Thomas W Brown, R.N.

[email protected]

(301) 402-7823

Email the study team

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Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

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Eligibility criteria

Inclusion

ability to sign informed consent

healthy male or female

18-85 years of age

ability to sign informed consent

healthy, male or female

18-65 years of age

willingness to provide concurrent blood sample

Exclusion

pregnancy

weight \<110 pounds

history of heart, lung, kidney disease, chronic anemia or bleeding disorders

a known bleeding disorder, low platelets (\<100k) or taking medications that interfere with blood clotting, such as aspirin, non-steroidal anti-inflammatory agents or warfarin

anemia (hemoglobin less than 12.3 mg/dL)

evidence of an immune deficiency, such as HIV infection or cancer

pregnancy

taking a medication that affects the immune response within the past month, including oral, intravenous, or injectable steroids

allergic to xylocaine

have taken an investigational drug in the last 6 months

any other medical condition that the investigator feels puts the participant at too high a risk for participation

warfarin and/or heparin treatment will not be stopped so that a subject can participate in this protocol. If warfarin or heparin was recently discontinued, a subject can be enrolled, but no bone marrow procedures will be performed until the PT is \< 15.5 seconds and the PTT is within normal range. For other agents that interfere with blood clotting without prolonging the PT, a 7- day washout period will be required before bone marrow sampling, skin biopsy or lumbar puncture.

Previous diagnosis of central nervous system pathology (including tumors,

History of spinal surgery with hardware placement

History of any spinal surgery or injections of the lumbosacral spine

Headache on the day of donation

History of keloid or abnormal scar formation

What this trial measures

- To provide an IRB-approved mechanism for the collection of peripheral blood, urine, sputum, stool, cerebrospinal fluid, skin biopsy and bone marrow samples from paid, volunteer donors for use in in vitro studies.50 years
\- To provide adequate and complete informed consent to the donors of research blood samples, and to assure that the education, counseling and protection of the study subjects from research risks is performed in accordance with IRB, OHRP, and other applicable Federal regulatory standards.

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