Magnetic Resonance Spectroscopy Studies of Cardiac Muscle Metabolism
This study is looking at how the heart's energy system (metabolism) works in people with and without heart conditions. Researchers are using a special MRI scan called magnetic resonance spectroscopy (MRS) to measure chemicals in the heart that show how it's using energy. They want to see if heart failure is linked to reduced energy in the heart. You could join if you are over 18 and have no heart disease, or if you have certain heart conditions like dilated cardiomyopathy (a weakened heart muscle), left ventricular hypertrophy (thickened heart muscle), or coronary artery disease (blocked heart arteries). The study aims to measure the levels of phosphocreatine/adenosine triphosphate (PCr/ATP) and creatine kinase (CK) flux in your heart using MRS. The current status of this study is unclear, and it plans to enroll up to 500 participants.
- Study design
- This is an observational study that plans to include up to 500 participants. It is not testing a specific drug or treatment.
- What's involved
- You would undergo magnetic resonance spectroscopy (MRS) at the time of measurement. The record does not specify the number of visits or other procedures.
- Compensation
- Not stated in the trial record.
- Follow-up
- The primary measurements are taken at the time of magnetic resonance spectroscopy (MRS). No further follow-up is specified.
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Magnetic Resonance Spectroscopy Studies of Cardiac Muscle Metabolism
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Robert G. Weiss, MD · PRINCIPAL_INVESTIGATOR · Johns Hopkins University
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- Phosphocreatine/adenosine triphosphate (PCr/ATP) and creatine kinase (CK) fluxAt time of magnetic resonance spectroscopy (MRS)
Can non-invasive magnetic resonance imaging and spectroscopy techniques be developed, validated, and implemented on clinical MR scanners in order to address the questions of a.) the extent to which myocardial high-energy phosphate (HEP), creatine (Cr), or sodium concentrations change in response to and after transient ischemia or chronic ischemic injury, b.) the extent to which myocardial high-energy phosphates, creatine, or sodium concentrations as well as HEP flux are altered in cardiomyopathic patients with and without/ congestive heart failure, c.) can spatial differences in cardiac metabolites (HEP, Cr) or ions (Na) induced by ischemic injury be identified with novel, non-invasive imaging techniques?