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Observational Study of Cell Changes in Lung, Esophagus, and Lung Lining Cancers

This observational study is looking at cell changes in people with cancers of the lung, esophagus, or the lining of the lung (pleura). Researchers want to understand how these cancers develop and progress by studying changes in chromatin (the material that makes up chromosomes inside cells). The goal is to collect tissue and blood samples from patients to help identify suitable candidates for future treatment studies and to support research into new treatments. You may be able to join if you have a suspicious lesion or a confirmed diagnosis of lung cancer, esophageal cancer, malignant pleural mesothelioma, or other thoracic cancers, including those that have spread to the lungs or pleura from other parts of the body. The study is currently recruiting, but the exact status is unclear.

Study design
This is an observational study, meaning researchers will collect information and samples without providing a specific treatment. It aims to enroll 1559 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoints, which involve obtaining specimens and evaluating patients for other protocols, are measured at open-ended timeframes.

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NCT00242723

Evaluation of Cell Changes in Blood and Tissue in Cancers of the Lung, Esophagus and Lung Lining

Recruiting
Not specifiedAges 2+Observational
National Cancer Institute (NCI)
~1,559 participants
Updated 2026-08-27 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Permit long-term follow-up of study participants for research to ascertain if gene expression and DNA methylation profiles coincide with response to therapy
Measured over open-ended
+2 more outcomes measured

Conditions

Thoracic Cancers
Malignant Pleural Mesotheliomas NOS
Lung Cancer NOS
Esophageal Cancers NOS
Cancers of Non Thoracic Origin With Metastases to the Lungs or Pleura
Thoracic Malignancies

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Cancers of Non-Thoracic Origin with Thoracic MetastasesChest Wall NeoplasmEsophageal CarcinomaLung CarcinomaMediastinal NeoplasmPleural Malignant MesotheliomaPotentially Malignant or Suspicious LesionsThymomaThymus Carcinoma

Where it's being run

1 sites across 1 states
Maryland1

Study leadership

  • David S Schrump, M.D. · PRINCIPAL_INVESTIGATOR · National Cancer Institute (NCI)

Who to contact

Rebecca B Alexander
[email protected]
(240) 781-4037
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Have physical examination parameters within acceptable limits by standard of practice guidelines prior to clinically indicated surgical procedure (e.g., biopsy or surgery),
Be aware of the nature of his/her illness,
Must be willing to undergo clinically indicated standard intervention that may include endoscopic biopsies of tumor and adjacent normal tissues (i.e., other tissue necessary to obtain negative margins per standard of care surgical processes) as a part of their standard of care treatment plan.

What this trial measures

  • Permit long-term follow-up of study participants for research to ascertain if gene expression and DNA methylation profiles coincide with response to therapyopen-ended

    Long-term follow-up visits at intervals based on participant's clinical status, to include history and medical exam, collection of research blood and urine; additional tissue from clinically indicated surgery/biopsy may be collected if available

  • Permit evaluation of adult patients referred to the Thoracic Surgery Branch, NCI in order to identify individuals who will be suitable candidates for treatment/intervention protocolsopen-ended

    Evaluation of adult patients referred to the Thoracic Surgery Branch, NCI in order to identify individuals who will be suitable candidates for treatment/intervention research protocols

  • Obtain specimens for research from study participantsopen-ended

    Specimens for research (tumor and adjacent normal tissues from clinically indicated biopsy or surgery, and blood, urine); research samples may be used for germline testing and ex vivo cell lines (autologous tumor cell lines and EBV-transformed B cell lines)