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Outcomes After Esophagectomy for Esophageal Cancer

This observational study is looking at the results of surgery for esophageal cancer, specifically comparing two types of surgery: minimally invasive esophagectomy (MIE) and open esophagectomy. Researchers want to understand both standard medical outcomes (like complications or how long people live) and how these surgeries affect your quality of life. You might be able to join if you are 18 or older and are scheduled for either MIE or open esophagectomy. The study will measure changes in your quality of life using questionnaires at 4, 6, and 12 months after surgery. The current status of this study is unclear, and it aims to include about 3500 participants.

Study design
This is an observational study, meaning researchers will watch and collect information without giving you a specific treatment. It plans to enroll about 3500 participants.
What's involved
You would complete quality of life and heartburn questionnaires before your surgery and at set times afterwards.
Compensation
Not stated in the trial record.
Follow-up
Your quality of life will be measured at 4, 6, and 12 months after your surgery.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT00260559

Outcomes After Esophagectomy With a Focus on Minimally Invasive Esophagectomy and Quality of Life

Recruiting
Not specifiedAges 18+Observational
University of Pittsburgh
~3,500 participants
Updated 2026-04-14 on ClinicalTrials.gov
What's tested:Questionnaires

At a glance

Recruiting sites
2 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change from baseline in SF36 Quality of Life Questionnaire at 4 month postoperative
Measured over Baseline and 4 month postoperative
+6 more outcomes measured

Conditions

Esophagectomy
Esophageal Cancer

Explore related trials

Esophageal Carcinoma

NCT00260559

Where you'd take part

This study runs at 2 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • University of Pittsburgh Medical Center - Department of Cardiothoracic Surgery

    Pittsburgh, Pennsylvaniastudy coordinator listed

    Recruiting

  • UPMC - Hillman Cancer Center

    Pittsburgh, Pennsylvaniastudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • James D Luketich, MD · PRINCIPAL_INVESTIGATOR · UPMC - Department of Cardiothoracic Surgery

Who to contact

Julie A Ward, BSN
[email protected]
412-647-8583
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

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Eligibility criteria

Inclusion

Patients scheduled for MIE (Minimally Invasive Esophagectomy)
Patients scheduled for open esophagectomy
Signed informed consent

Exclusion

Patients who are unable to comprehend or complete the QOL instruments.
Patients less than 18 years of age.

What this trial measures

  • Change from baseline in SF36 Quality of Life Questionnaire at 4 month postoperativeBaseline and 4 month postoperative

    The SF36 is an eight dimension Quality of Life Measurement. It provides two main Component scores, Physical Component Summary (PCS) and the Mental Component Summary (MCS). It includes 8 scales or sub-scores: Physical function (PF), role physical (RP), Bodily pain (BP), general health (GH), vitality (VT), social functioning (SF), role emotional (RE), and mental health (MG). Each scale contributes a different amount to the component scores, which are calculated by a special algorithm that is licensed by Optum. The Component and sub-scales have a minimum of 0 and a maximum of 100. The higher the score represent the higher quality of life/less disability.

  • Change from baseline in SF36 Quality of Life Questionnaire at 6 month postoperativeBaseline and 6 month postoperative

    The SF36 is an eight dimension Quality of Life Measurement. It provides two main Component scores, Physical Component Summary (PCS) and the Mental Component Summary (MCS). It includes 8 scales or sub-scores: Physical function (PF), role physical (RP), Bodily pain (BP), general health (GH), vitality (VT), social functioning (SF), role emotional (RE), and mental health (MG). Each scale contributes a different amount to the component scores, which are calculated by a special algorithm that is licensed by Optum. The Component and sub-scales have a minimum of 0 and a maximum of 100. The higher the score represent the higher quality of life/less disability.

  • Change from baseline in SF36 Quality of Life Questionnaire at 12 month postoperativeBaseline and 12 month postoperative

    The SF36 is an eight dimension Quality of Life Measurement. It provides two main Component scores, Physical Component Summary (PCS) and the Mental Component Summary (MCS). It includes 8 scales or sub-scores: Physical function (PF), role physical (RP), Bodily pain (BP), general health (GH), vitality (VT), social functioning (SF), role emotional (RE), and mental health (MG). Each scale contributes a different amount to the component scores, which are calculated by a special algorithm that is licensed by Optum. The Component and sub-scales have a minimum of 0 and a maximum of 100. The higher the score represent the higher quality of life/less disability.

  • Change from baseline in SF36 Quality of Life Questionnaire at 18 monthBaseline and 18 month postoperative

    The SF36 is an eight dimension Quality of Life Measurement. It provides two main Component scores, Physical Component Summary (PCS) and the Mental Component Summary (MCS). It includes 8 scales or sub-scores: Physical function (PF), role physical (RP), Bodily pain (BP), general health (GH), vitality (VT), social functioning (SF), role emotional (RE), and mental health (MG). Each scale contributes a different amount to the component scores, which are calculated by a special algorithm that is licensed by Optum. The Component and sub-scales have a minimum of 0 and a maximum of 100. The higher the score represent the higher quality of life/less disability.

  • Change from baseline in SF36 Quality of Life Questionnaire at 24 monthBaseline and 24 month postoperative

    The SF36 is an eight dimension Quality of Life Measurement. It provides two main Component scores, Physical Component Summary (PCS) and the Mental Component Summary (MCS). It includes 8 scales or sub-scores: Physical function (PF), role physical (RP), Bodily pain (BP), general health (GH), vitality (VT), social functioning (SF), role emotional (RE), and mental health (MG). Each scale contributes a different amount to the component scores, which are calculated by a special algorithm that is licensed by Optum. The Component and sub-scales have a minimum of 0 and a maximum of 100. The higher the score represent the higher quality of life/less disability.

  • Change from baseline in SF36 Quality of Life Questionnaire at 30 monthBaseline and 30 month postoperative

    The SF36 is an eight dimension Quality of Life Measurement. It provides two main Component scores, Physical Component Summary (PCS) and the Mental Component Summary (MCS). It includes 8 scales or sub-scores: Physical function (PF), role physical (RP), Bodily pain (BP), general health (GH), vitality (VT), social functioning (SF), role emotional (RE), and mental health (MG). Each scale contributes a different amount to the component scores, which are calculated by a special algorithm that is licensed by Optum. The Component and sub-scales have a minimum of 0 and a maximum of 100. The higher the score represent the higher quality of life/less disability.

  • Change from baseline in SF36 Quality of Life Questionnaire at 36 monthBaseline and 36 month postoperative

    The SF36 is an eight dimension Quality of Life Measurement. It provides two main Component scores, Physical Component Summary (PCS) and the Mental Component Summary (MCS). It includes 8 scales or sub-scores: Physical function (PF), role physical (RP), Bodily pain (BP), general health (GH), vitality (VT), social functioning (SF), role emotional (RE), and mental health (MG). Each scale contributes a different amount to the component scores, which are calculated by a special algorithm that is licensed by Optum. The Component and sub-scales have a minimum of 0 and a maximum of 100. The higher the score represent the higher quality of life/less disability.