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Esophageal Cancer Risk Registry

This study aims to find markers in your blood and tissue that could help us understand the risk factors for developing and progressing esophageal cancer (cancer of the tube connecting your throat to your stomach). We are collecting medical history, blood, and tissue samples from patients with esophageal disorders. By identifying genetic and lifestyle risk factors, we hope to improve early detection and prevention of esophageal cancer. You may be eligible if you are 18 or older and have known or suspected esophageal cancer, Barrett's metaplasia (a condition that can lead to cancer), symptomatic GERD (Gastroesophageal Reflux Disease, or chronic heartburn), achalasia (a swallowing disorder), or a hiatal hernia (when part of your stomach pushes through your diaphragm). This is an observational study, meaning we are collecting information without giving you a specific treatment. We plan to enroll 7000 participants.

Study design
This is an observational study, meaning researchers are collecting information without providing a specific treatment. It aims to enroll 7000 participants.
What's involved
You would complete a questionnaire about your health and family history. Blood samples would be taken during surgery or routine follow-up visits. Tissue samples from biopsies, oral samples (saliva), or washings may also be collected during surgery or endoscopy.
Compensation
Not stated in the trial record.
Follow-up
Not specified.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT00260585

Esophageal Cancer Risk Registry

Recruiting
Not specifiedAges 18+Observational
University of Pittsburgh
~7,000 participants
Updated 2026-04-14 on ClinicalTrials.gov
What's tested:Survey of client health, personal habits, family historyBlood specimen for non-DNA and DNA partsBiopsy of esophageal/stomach tissue, lymph nodes, tumorBiopsies, oral (saliva) and/or secretions, washings or mucosal scrapings/brushing from routine clinical surveillance endoscopies

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring

A primary outcome measure isn't published for this study.

Conditions

Esophageal Cancer
Gastroesophageal Reflux Disease (GERD)
Esophageal Diseases
Hiatal Hernia
Esophageal Achalasia

Explore related trials

AchalasiaBarrett EsophagusEsophageal CarcinomaGastroesophageal Reflux DiseaseHiatal Hernia

Where it's being run

1 sites across 1 states
Pennsylvania1

Study leadership

  • James D. Luketich, MD · PRINCIPAL_INVESTIGATOR · Department of Cardiothoracic Surgery

Who to contact

Julie A Ward, BSN
[email protected]
412-647-8583
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

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Eligibility criteria

Inclusion

Known or suspected esophageal or gastroesophageal junction malignancy
Known Barrett's metaplasia
Clinical management of symptomatic gastroesophageal reflux disease (GERD)
Achalasia
Hiatal hernia

Exclusion

Elevated pre-operative bloodwork will not have the additional biopsies taken.
Platelet count less than 150,000, partial thromboplastin time (PTT) of 50 or above, and/or International Normalized Ratio (INR) of 1.8 or above will not have the additional biopsies taken.