This observational study is looking for genetic and immune system changes that play a role in how lung cancer develops and grows. Researchers will collect tissue samples during surgery or biopsy, including samples from the main airway (major carinal area) and any suspicious areas in the breathing tubes (bronchial tree). They will also collect fluid from the lungs (bronchoalveolar lavage or BAL) and evaluate tumor tissue for DNA changes. The goal is to find out if certain molecular markers increase your risk of lung cancer. You can join if you are 18 or older, have a confirmed lung cancer diagnosis, lung cancer that has spread from another part of the body, mesothelioma, or a lung lesion highly suspicious for cancer, and are scheduled for or have already had a biopsy or surgery for a lung mass. The study status is currently unclear.

Study design

This is an observational study planning to include 6000 participants. It is not testing a specific treatment but rather observing and collecting information.

What's involved

You would undergo biopsies of the major carinal area and abnormal/suspicious bronchial tree areas, a bronchoalveolar lavage (BAL), and have your tumor evaluated for DNA mutations. These procedures are performed during surgery.

Compensation

Not stated in the trial record.

Follow-up

The primary goal is to measure the risk of lung cancer associated with molecular markers, with no specific time frame mentioned for follow-up.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.