Genetic Study of Barrett's Esophagus and Esophageal Cancer
This observational study is looking into the genetic causes of Barrett's esophagus (a condition where the lining of the esophagus changes) and esophageal adenocarcinoma (a type of esophageal cancer). Researchers want to understand how inherited genetic changes lead to these conditions. You might be eligible if you have Barrett's esophagus or esophageal adenocarcinoma, or if you are a family member of someone with these conditions. Participants will undergo a standard upper endoscopy (a procedure to look at your upper digestive system) and may also use a Balloon Capsule Device to collect a tissue sample from your esophagus. The goal is to find better ways to prevent or detect esophageal cancer early. The study is currently unclear on its recruitment status and plans to enroll 2000 people.
- Study design
- This is an observational study with a planned enrollment of 2000 participants. It is not specified if it is randomized or blinded.
- What's involved
- You will undergo a standard upper endoscopy and may use a Balloon Capsule Device to collect a tissue sample. DNA and RNA markers will be measured at 1 week.
- Compensation
- Not stated in the trial record.
- Follow-up
- DNA and RNA markers will be measured at 1 week after the procedure.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Genetic Determinants of Barrett's Esophagus and Esophageal Adenocarcinoma
At a glance
Conditions
NCT00288119
Where you'd take part
This study runs at 10 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
Cleveland Clinic
Cleveland, Ohiostudy coordinator listed
Recruiting
Columbia University Medical Center
New York, New Yorkstudy coordinator listed
Recruiting
Fred Hutchinson Cancer Research Center, UWMC
Seattle, Washingtonstudy coordinator listed
Recruiting
Johns Hopkins Hospital
Baltimore, Marylandstudy coordinator listed
Recruiting
Mayo Clinic
Rochester, Minnesotastudy coordinator listed
Recruiting
University Hospitals of Cleveland
Cleveland, Ohiostudy coordinator listed
Recruiting
University of North Carolina at Chapel Hill
Chapel Hill, North Carolinastudy coordinator listed
Recruiting
University of Pennsylvania
Philadelphia, Pennsylvaniastudy coordinator listed
Recruiting
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Study leadership
- Amitabh Chak, MD · PRINCIPAL_INVESTIGATOR · University Hospitals Cleveland Medical Center, CWRU, Cleveland, OH
- Gary W Falk, MD, MS · PRINCIPAL_INVESTIGATOR · University of Pennsylvania
- William Grady, MD · PRINCIPAL_INVESTIGATOR · Fred Hutchinson Cancer Research Center, UWMC, Seattle, WA
- Nicholas J Shaheen, M.D. · PRINCIPAL_INVESTIGATOR · University of North Carolina, Chapel Hill
- Ganapathy Prasad, M.D. · PRINCIPAL_INVESTIGATOR · Mayo Clinic
- Marcia Canto, M.D. · PRINCIPAL_INVESTIGATOR · Johns Hopkins University
- John Dumont, D.O. · PRINCIPAL_INVESTIGATOR · University Hospitals Cleveland Medical Center
- Prashanthi Thota, M.D. · PRINCIPAL_INVESTIGATOR · The Cleveland Clinic
- Jean Wang, MD · PRINCIPAL_INVESTIGATOR · Washington University School of Medicine
- Julian Abrams, MD · PRINCIPAL_INVESTIGATOR · Columbia University
- Andrew Kaz, MD · PRINCIPAL_INVESTIGATOR · VA Puget Sound Health Care System
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
What this trial measures
- Assay of DNA and RNA markers1 week
The Balloon tip is collected and sent to the PacificDx Laboratory in Irvine California to test for DNA extraction