This observational study is looking at the effects of cancer and its treatments on mothers and their children when cancer occurs during pregnancy. Researchers want to understand how mothers diagnosed with cancer during pregnancy fare over time. They also want to see if children exposed to cancer treatments like chemotherapy, radiation therapy, or targeted therapy before birth develop normally, especially regarding their brain and heart health. The study aims to enroll 5000 women aged 18 and older who have a histologically proven (confirmed by looking at tissue under a microscope) cancer diagnosis during pregnancy or within five years after. This study does not involve new treatments; it observes what happens to mothers and children in these situations.

Study design

This is an observational study aiming to enroll 5000 participants. It is not testing a new treatment but rather observing outcomes for mothers and children.

What's involved

If you are a mother, you may be asked to provide a blood sample, and umbilical cord blood and placental biopsies may be collected. You might also complete questionnaires. If your child is part of the study, they will have regular check-ups until age 18, and then cardiologic assessments and questionnaires every five years until age 43. MRI sessions are optional at certain ages.

Compensation

Not stated in the trial record.

Follow-up

Mothers will be followed up at an anticipated time. Children will have regular check-ups until age 18, and then follow-up with cardiologic assessments and questionnaires every five years until age 43.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.