Observational Study of Biliary Atresia in Infants and Children
This study is looking into biliary atresia (a rare liver disease in infants) to understand what causes it and how it progresses, especially in older children. Researchers want to identify the genes involved in biliary atresia and learn more about how the disease affects children who are not undergoing liver transplantation. They will collect clinical information, genetic material, and body fluid samples from about 1265 participants. To join, you must have a confirmed diagnosis of biliary atresia and be between 6 months and 20 years old. The main goal is to find the specific genes linked to biliary atresia.
- Study design
- This is an observational study, meaning researchers will collect information without giving any new treatments. It plans to include about 1265 participants.
- What's involved
- Specimens for genetic analysis are collected once, usually at the beginning of the study. Participants enrolled at 20 years of age will have one visit.
- Compensation
- Not stated in the trial record.
- Follow-up
- Not specified.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Biliary Atresia Study in Infants and Children
At a glance
Conditions
Where it's being run
16 sites across 14 statesStudy leadership
- Sanjiv Harpavat, MD · STUDY_CHAIR · Texas Children's/Baylor College of Medicine
- Ed Doo, MD · STUDY_DIRECTOR · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- John C Magee, MD · PRINCIPAL_INVESTIGATOR · University of Michigan
- Lisa Henn, PhD · PRINCIPAL_INVESTIGATOR · Arbor Research Collaborative for Health - Data Coordinating Center
- Katrina Loh, MD · STUDY_DIRECTOR · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Who to contact
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What this trial measures
- To identify the gene or genes implicated in the etiology of BASpecimens for this aim are collected once during study, usually at baseline.
The genetics of BA may be investigated on two levels. The first is to identify a group of patients whose etiology is a result of a genetic defect and the second is to examine the influence of genetics on disease acquisition.