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Identifying Genetic Risk for Primary Graft Dysfunction After Lung Transplant

This observational study aims to understand why some people develop primary graft dysfunction (PGD), a severe lung injury, after a lung transplant. PGD can cause fluid buildup in the lungs (pulmonary edema) and low blood oxygen (hypoxemia), and it's a major concern after surgery. Researchers want to find specific genetic characteristics in both lung donors and recipients that might increase the risk of PGD. By identifying these genetic factors, doctors might be able to predict who is most at risk, potentially allowing more people to receive life-saving lung transplants. You can join if you are between 15 and 65 years old and are having a lung transplant. The study will look at PGD within the first 72 hours after your transplant. The current recruitment status is unclear.

Study design
This is an observational study planning to enroll 1150 participants. It is not a treatment study, but rather aims to identify genetic factors related to a complication after lung transplant.
What's involved
Blood samples will be collected from lung donors and from you before surgery, immediately after surgery, and 24 hours after surgery.
Compensation
Not stated in the trial record.
Follow-up
The primary outcome, primary graft dysfunction, is measured within the first 72 hours after lung transplantation.

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NCT00457847

Identifying Genetic Characteristics That Increase Risk of Primary Graft Dysfunction Following Lung Transplantation

Active, Not Recruiting
Not specifiedAges 15–65Observational
University of Pennsylvania
~1,150 participants
Updated 2026-07-22 on ClinicalTrials.gov

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Primary graft dysfunction
Measured over First 72 hours post lung transplantation

Conditions

Primary Graft Dysfunction
Lung Transplantation

Explore related trials

Lung Transplantation

Where it's being run

1 sites across 1 states
Pennsylvania1

Study leadership

  • Jason D. Christie, MD · PRINCIPAL_INVESTIGATOR · University of Pennsylvania

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Undergoing lung transplant surgery

What this trial measures

  • Primary graft dysfunctionFirst 72 hours post lung transplantation

    ISHLT standard definition and grading system will be used