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Understanding Energy and Outcomes in Cancer Surgery

This observational study is looking at how your body's energy levels before cancer surgery might affect your recovery. Researchers will use a Cardiopulmonary Exercise Test (CPET), which involves pedaling on a stationary bicycle, to measure your fitness. They want to see if these measurements can help predict your risk of complications after surgery for abdominal or pelvic cancer. This study is for people aged 18 and older who have been newly diagnosed with esophageal or lung cancer and are undergoing treatments like chemotherapy, radiation therapy, or immunotherapy before surgery. The main goal is to see if your fitness at the start of the study, and 30 days after surgery, relates to any health issues you might experience. The current status of this study is unclear.

Study design
This is an observational study planning to enroll 200 participants. It is not specified if it is randomized or blinded.
What's involved
You would undergo a Cardiopulmonary Exercise Test (CPET) before and after your neoadjuvant therapy. Researchers will also monitor for any health issues for 30 days after your surgery.
Compensation
Not stated in the trial record.
Follow-up
Participants will be monitored for morbid events for 30 days postoperatively.

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NCT00493688

A Study to Determine Whether Perioperative Energy Dynamics Correlates With Postoperative Outcomes

Recruiting
Not specifiedAges 18+Observational
M.D. Anderson Cancer Center
~200 participants
Updated 2026-07-15 on ClinicalTrials.gov
What's tested:Cardiopulmonary Exercise Testing (CPET)

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Patient Perioperative Risk
Measured over Baseline + 30 days postoperatively monitoring for morbid events

Conditions

Abdominal Cancer
Pelvic Cancer

Explore related trials

Esophageal CarcinomaLung Carcinoma

Where it's being run

1 sites across 1 states
Texas1

Study leadership

  • Anh Dang, MD · PRINCIPAL_INVESTIGATOR · M.D. Anderson Cancer Center

Who to contact

Anh Q Dang, MD
[email protected]
713-745-5025
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Participants 18 years of age or older.
Participants with newly diagnosed esophageal and lung cancer undergoing neoadjuvant chemotherapy, radiation therapy, and/or immunotherapy.
Participants who have signed the consent form to participate in the study.
Participants must have been evaluated in the Perioperative Evaluation and Management (POEM) Center or by a staff Anesthesiologist.
All laboratory and diagnostic evaluations required or used to evaluate the patient must be completed. All participants must be approved to undergo anesthesia by the standards of the POEM Center.
No samples belonging to vulnerable populations (children, pregnant women, cognitively impaired adults or prisoners) will be allowed from participation.

Exclusion

Participant is under age 18.
Participant is unwilling to sign consent.
Participant is unable to exercise (bedridden or wheel chair bound).
Participant is enrolled in another study deemed by the investigator to affect oxygen metabolic efficiency and not presently the standard of care at MDACC.
Participant's condition is deemed unsatisfactory for surgery after the preanesthetic evaluation.
Participant has had a myocardial infarction within three months of the preanesthetic evaluation or presents with new or unstable angina.
Participant has a history of a cerebrovascular accident or transit ischemic attacks within three months of the preanesthetic evaluation.
Participant has a history of a pulmonary embolic event within three months of the preanesthetic evaluation.
Participant is known to have acute or chronic deep vein thrombosis.
Participant is pregnant.

What this trial measures

  • Patient Perioperative RiskBaseline + 30 days postoperatively monitoring for morbid events

    Measure preoperative energy reserve capacity (fitness) using perioperative energy dynamics where fitness is defined by gas exchange data during cardiopulmonary exercise testing as method of assessing perioperative risk