Observational Study on Risk Factors for Primary Graft Dysfunction After Lung Transplant

This observational study is looking at risk factors for Primary Graft Dysfunction (PGD), a serious complication that can happen after a lung transplant. Researchers want to see if high levels of certain chemicals in your blood, particularly those involved in bleeding and clotting (like protein C) or markers of oxidant stress (which can damage cells), might increase your chance of developing PGD. You could be eligible if you are between 13 and 68 years old and are having a lung or combined heart and lung transplant. The study aims to understand if these chemical levels are linked to PGD, which is measured within 72 hours after transplantation. The study status is unclear, and it plans to enroll 1150 participants.

Study design
This is an observational study, meaning researchers will collect information without giving any specific treatments. It plans to include 1150 participants.
What's involved
You would have blood samples collected before, immediately after, and 24 hours after your surgery. Researchers will also review your medical records.
Compensation
Not stated in the trial record.
Follow-up
The primary outcome, Primary Graft Dysfunction, is measured within 72 hours following transplantation.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT00552357

Risk Factors That Increase the Chance of Developing Primary Graft Dysfunction After Lung Transplantation

Recruiting
Not specifiedAges 13–68Observational
University of Pennsylvania
~1,150 participants
Updated 2026-07-22 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Primary graft dysfunction, defined by the ISHLT criteria
Measured over Measured within 72 hours following transplantation
Primary Graft Dysfunction
Lung Transplantation
1 sites across 1 states
Pennsylvania1
  • Jason D. Christie, MD · PRINCIPAL_INVESTIGATOR · University of Pennsylvania
E.J. Demissie, MSN
Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Undergoing lung or combined heart and lung transplantation

Exclusion

Undergoing combined organ transplantation other than heart and lung transplantation
  • Primary graft dysfunction, defined by the ISHLT criteriaMeasured within 72 hours following transplantation