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Studying Progression of GERD and Barrett's Esophagus

This study is looking at how gastroesophageal reflux disease (GERD) and Barrett's esophagus (a condition where the lining of the esophagus changes) progress over time. Researchers want to understand what factors, like smoking or family history, might lead to esophageal cancer. They are collecting information from patients with GERD and Barrett's esophagus to identify who might be at higher risk for developing more serious conditions like dysplasia (abnormal cell growth) and esophageal adenocarcinoma (a type of cancer). The goal is to find ways to better identify and help patients prevent these conditions. This is an observational study, meaning no specific treatments are being tested. Over 585 patients have joined this study so far at the Kansas City VA Medical Center.

Study design
This is an observational study aiming to enroll 3000 participants. It is not testing a specific drug or intervention.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for 5 or more years to track the development of dysplasia and adenocarcinoma.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT00574327

Progression of Gastroesophageal Reflux Disease and Barrett's Esophagus and the Creation of a Barrett's Registry

Recruiting
Not specifiedAges 18+Observational
Midwest Biomedical Research
~3,000 participants
Updated 2023-03-16 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
The goal of this study is to follow GERD and BE pts prospectively for development of dysplasia and adenocarcinoma, to identify factors responsible for progression of GERD to BE to dysplasia and adenocarcinoma.
Measured over 5 plus years

Conditions

Barrett's Esophagus
Gastroesophageal Reflux Disease
Esophageal Adenocarcinoma

Explore related trials

Barrett EsophagusEsophageal AdenocarcinomaGastroesophageal Reflux Disease

Where it's being run

1 sites across 1 states
Missouri1

Study leadership

  • Prateek Sharma, MD · PRINCIPAL_INVESTIGATOR · Department of Veterans Affairs Medical Center of Kansas City

Who to contact

April D Higbee, RN, BSN
[email protected]
816-861-4700 · ext. 57456
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Kansas City VA Patients with confirmed BE with and without dysplasia and patients with reflux disease (patients/cases); patients with other indicators for endoscopy such as anemia, weight loss, diarrhea, but without GERD and PE (controls).

Exclusion

Patients with uncontrolled significant comorbidities such as cardiovascular, pulmonary, renal, hepatic or metabolic diseases.
Presence of anticoagulation that would increase risk from biopsies
Patients unable to provide history
Patients with dyspepsia

What this trial measures

  • The goal of this study is to follow GERD and BE pts prospectively for development of dysplasia and adenocarcinoma, to identify factors responsible for progression of GERD to BE to dysplasia and adenocarcinoma.5 plus years