Pilot Study for Allergic Airway Inflammation in Asthma

This study is looking for people aged 18 to 50 with allergic asthma to better understand what causes inflammation in their airways. You might be able to join if you have asthma, a history of allergic symptoms to cat or dust mite, and a positive skin prick test to these allergens. The study involves a procedure called Bronchoscopy, Segmental Allergen Challenge, and Broncheoalveolar Lavage. This procedure involves looking into your airways with a thin tube (bronchoscopy) and collecting fluid from your lungs after a small amount of cat or mite allergen is introduced. Researchers will then measure airway inflammation at 1, 6, or 24 hours to see how your body reacts. The goal is to identify factors that bring inflammatory cells to the airways in people with asthma. The current status of this study is unclear, and it plans to enroll 313 participants.

Study design
This is an interventional study, meaning participants will receive a specific procedure. It plans to enroll 313 participants.
What's involved
You would undergo Bronchoscopy, Segmental Allergen Challenge, and Broncheoalveolar Lavage, with measurements taken at 1, 6, or 24 hours.
Compensation
Not stated in the trial record.
Follow-up
Airway inflammation will be measured at 1, 6, or 24 hours after the intervention.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT00595491

Pilot Study to Identify the Mediators and Inflammatory Cell Surface Receptors Involved in Allergic Airway Inflammation

Recruiting
PHASE1Ages 18–50InterventionalBasic science
Benjamin Medoff
~313 participants
Updated 2025-09-25 on ClinicalTrials.gov
What's tested:Bronchoscopy, Segmental Allergen Challenge, and Broncheoalveolar Lavage

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
airway inflammation
Measured over 1,6, or 24 hours
Asthma
1 sites across 1 states
Massachusetts1
  • Benjamin D Medoff, MD, PhD · PRINCIPAL_INVESTIGATOR · Massachusetts General Hospital

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  • airway inflammation1,6, or 24 hours