This study is looking at the tiny living things (microbes like bacteria, fungi, and viruses) that live on human skin. Researchers want to understand how these microbes contribute to healthy skin and how they might change in people with skin conditions like eczema (also known as atopic dermatitis or AD). They will compare skin microbes from healthy volunteers with those from people who have moderate to severe eczema. They are also interested in people aged 2-40 with certain inherited immune disorders (HIES, WAS, or DOCK8 immunodeficiency) because these conditions often involve skin problems similar to eczema. The main goal is to learn more about the role of these microbes in skin health and disease.

Study design

This is an observational study, meaning researchers will study people without giving them a specific treatment. It plans to enroll up to 530 participants.

What's involved

Not specified in the trial record.

Compensation

Not stated in the trial record.

Follow-up

The primary endpoints, which are measures of what the study is trying to find out, are ongoing.

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