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Genetic Variants and Susceptibility to Diseases of Prematurity in Very Low Birth-Weight Infants

This study is looking at whether small differences in your baby's genes (gene variations) might make them more likely to develop certain health problems common in premature infants. These problems include chronic lung disease (CLD), necrotizing enterocolitis (NEC), sepsis, patent ductus arteriosus (PDA), and intraventricular hemorrhage (IVH). Researchers will compare gene variations in premature infants who develop these conditions to those who don't. The goal is to understand if these genetic differences increase the risk. This study is for infants born weighing less than 1500 grams. It is not currently recruiting new participants, as its status is unclear.

Study design
This is an observational study planning to include 1100 infants. It compares gene variations in infants who develop certain diseases of prematurity to those who do not.
What's involved
Participants will be followed for the duration of their hospital stay, which is expected to be an average of 6 to 8 weeks.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for the duration of their hospital stay, an expected average of 6 to 8 weeks.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT00710112

Genetic Variants and Susceptibility to Diseases of Prematurity in Very Low Birth-Weight Infants

Recruiting
Not specifiedAll AgesObservational
Medical College of Wisconsin
~1,100 participants
Updated 2026-01-26 on ClinicalTrials.gov
What's tested:gene variations

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
To determine if small variations in certain genes predispose infants to the development of chronic lung disease and other diseases of prematurity
Measured over participants will be followed for the duration of hospital stay, an expected average of 6 to 8 weeks

Conditions

Chronic Lung Disease

Explore related trials

Chronic Lung DisorderIntraventricular Brain HemorrhageNecrotizing EnterocolitisPatent Ductus ArteriosusSepticemia

NCT00710112

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Children's Wisconsin

    Milwaukee, Wisconsinstudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • G. Ganesh Konduri, MD · PRINCIPAL_INVESTIGATOR · Medical College of Wisconsin

Who to contact

G. Ganesh Konduri, MD
[email protected]
414.266.6820
Email the study team

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Eligibility criteria

Inclusion

Infants born weighing less than 1500 grams

Exclusion

Infants born with congenital heart disease (other than patent ductus arteriosus)
major congenital anomalies of the GI tract, respiratory tract, or kidneys

What this trial measures

  • To determine if small variations in certain genes predispose infants to the development of chronic lung disease and other diseases of prematurityparticipants will be followed for the duration of hospital stay, an expected average of 6 to 8 weeks