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Observational Study on Blood Proteins in Heart Failure

This study is looking at two specific proteins in your blood to see if their levels increase during acute heart failure. These proteins are made when your heart isn't working as well as it should. Researchers want to understand if changes in these protein levels are linked to acute heart failure events. At this time, it's not known if these proteins are associated with heart failure. You might be able to join if you are over 18 and have stable or decompensated heart failure, regardless of how well your heart pumps (LVEF). You would also need to have symptoms like shortness of breath or swelling, and imaging evidence of heart failure. The study aims to follow participants for three years to see if they are hospitalized for heart failure, have a heart attack, stroke, or die. The current recruitment status is unclear.

Study design
This is an observational study, meaning researchers will watch and collect information without giving any specific treatments. It plans to include up to 500 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for up to three years to track events like hospitalization for heart failure, heart attack, stroke, or death.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT00762008

Circulating Markers That Underlie the Transition From Compensated Hypertrophy to Heart Failure

Recruiting
Not specifiedAges 18+Observational
UConn Health
~500 participants
Updated 2026-08-17 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Hospitalization for acute heart failure, myocardial infarction, stroke or death.
Measured over 3 years

Conditions

Acute Decompensated Heart Failure
Heart Failure

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NCT00762008

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • University of Connecticut Health Center

    Farmington, Connecticutno site contact published

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Bruce T. Liang, M.D. · PRINCIPAL_INVESTIGATOR · UConn Health

Who to contact

Kristen Siedlarz, MA
[email protected]
860-679-7549
Email the study team

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Eligibility criteria

Inclusion

Individuals aged \>18yrs
stable or decompensated heart failure, irrespective of LVEF
decompensated heart failure clinical symptoms such as dyspnea, rales, edema, elevated jugular venous pressure, or ascites
Imaging evidence of heart failure (cardiomegaly, poor contractile function or echocardiographic Doppler evidence of diastolic dysfunction or elevated right- or left-sided filling pressures)
Healthy individuals with no prior history of heart attack or heart failure will be recruited to use as controls.

Exclusion

Subjects who are unable to give informed consent
Subjects who had undergone cardiac or non-cardiac surgery in the 3 months before enrollment
Pregnant subjects are not excluded

What this trial measures

  • Hospitalization for acute heart failure, myocardial infarction, stroke or death.3 years