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Observational Study for Chest Pain with Non-Obstructive Coronary Arteries

This study is for people who experience chest pain or similar discomfort, but whose heart arteries don't show blockages. This condition is often called angina/ischemia with non-obstructive coronary arteries (ANOCA/INOCA). Researchers want to understand how common these conditions are, what causes them, and how they affect people over time. You would undergo standard heart tests like a coronary angiography (an X-ray of your heart's blood vessels), intravascular ultrasound (IVUS), and coronary pressure/flow wire testing, which may include challenges with acetylcholine and nitroglycerin. The study aims to identify different types of ANOCA and track your health for up to 15 years. The study is currently enrolling 2000 participants.

Study design
This is an observational study, meaning researchers will gather information without assigning specific treatments. It plans to enroll 2000 participants.
What's involved
You would have a blood draw, and undergo heart procedures including intravascular ultrasound and coronary pressure/flow wire testing. You may be contacted periodically for follow-up information for up to 15 years.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for up to 15 years to track major adverse cardiovascular events.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT00823563

Evaluation of Patients With Non-obstructive Coronary Arteries

Recruiting
Not specifiedAges 18+Observational
Stanford University
~2,000 participants
Updated 2025-06-05 on ClinicalTrials.gov
What's tested:30 cc blood drawIntravascular ultrasound (IVUS)Coronary pressure/flow wire testingCoronary pressure/flow testing: Acetycholine challengeProcedure: Coronary pressure/flow testing: Nitroglycerin challengeProcedure: Procedure: Coronary pressure/flow testing: Adenosine challenge

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Sex Differences in Endothelial Dysfunction, Microvascular Dysfunction, and Diffuse Plaque
Measured over Day of procedure (study day one)
+1 more outcome measured

Conditions

Chest Pain
Ischemia

Explore related trials

Chest PainIschemia

Where it's being run

1 sites across 1 states
California1

Study leadership

  • Jennifer A Tremmel, MD, MS · PRINCIPAL_INVESTIGATOR · Stanford University

Who to contact

Vedant Pargaonkar, MD
[email protected]
(650) 498-1195
Email the study team

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What this trial measures

  • Sex Differences in Endothelial Dysfunction, Microvascular Dysfunction, and Diffuse PlaqueDay of procedure (study day one)

    This outcome is to measure the prevalence of angina and non-obstructive coronary arteries (ANOCA) endotypes

  • Number of participants with major adverse cardiovascular events (MACE)15 years

    MACE - death, heart attack, revascularization, stroke