Collecting and Analyzing Tissue Samples for Non-Small Cell Lung Cancer

This research study is collecting and analyzing lung tissue samples from patients undergoing surgery for non-small cell lung cancer. The goal is to learn more about changes in RNA (a molecule important for making proteins) and identify biomarkers (biological signs) related to cancer. Researchers will use techniques like gene expression analysis, microarray analysis, and protein expression analysis on blood and lung tissue samples. You may be able to join if you are 18 to 120 years old, have non-small cell lung cancer that is clinical stage I or II, and are planning to have surgery to remove the cancer. The study aims to understand the protein and RNA patterns in these samples. The current status of this study is unclear, and it plans to enroll 4000 participants.

Study design
This is an observational, multicenter study. It plans to enroll 4000 participants.
What's involved
If you participate, excess tissue from your surgery that would normally be discarded will be collected. Your medical records will also be reviewed to gather information about your cancer diagnosis and treatment progress.
Compensation
Not stated in the trial record.
Follow-up
Your medical records will be reviewed to follow your progress in cancer treatment and tumor behavior after surgery, including recurrence and survival.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT00897117

Collecting and Analyzing Tissue Samples From Patients Undergoing Surgery for Non-Small Cell Lung Cancer

Recruiting
Not specifiedAges 18+Observational
Vanderbilt-Ingram Cancer Center
~4,000 participants
Updated 2026-08-20 on ClinicalTrials.gov
What's tested:gene expression analysismicroarray analysisprotein expression analysisbiologic sample preservation procedurelaboratory biomarker analysismatrix-assisted laser desorption/ionization time of flight mass spectrometry

At a glance

Recruiting sites
1 of 3 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Protein and RNA expression fingerprints from collected samples
Measured over after collection of designated samples
Lung Cancer
3 sites across 1 states
Tennessee3
  • Eric Grogan, MD · PRINCIPAL_INVESTIGATOR · Vanderbilt Medical Center
VICC Clinical Trials Information Program
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Eligibility criteria

Inclusion

Diagnosis of non-small cell lung cancer
Clinical stage I and II disease
Resectable disease and complete surgical resection planned
Treated on companion studies at Vanderbilt University, the Veterans Administration hospital, St. Thomas, and Vanderbilt-Ingram Cancer Center Affiliate Network
Tumor specimen samples must be available at resection

Exclusion

Chemotherapy before surgery
Radiotherapy before surgery
  • Protein and RNA expression fingerprints from collected samplesafter collection of designated samples