Pancreatic Adenocarcinoma Gene Environment Risk Study

This observational study, called the Pancreatic Adenocarcinoma Gene Environment Risk Study, aims to understand the factors that contribute to pancreatic cancer. Researchers are collecting information and samples from people with pancreatic cancer and those with other conditions affecting the pancreas, liver, or intestines. There are no specific interventions or treatments being tested in this study. The goal is to gather data over 10 years to identify connections between genes, environment, and pancreatic cancer. The study is currently recruiting a large number of participants, up to 10,000 people. To join, you must be at least 18 years old and have either a confirmed diagnosis of pancreatic adenocarcinoma (a type of pancreatic cancer) or certain other pancreatic, liver, or intestinal conditions.

Study design
This is an observational study with a planned enrollment of up to 10,000 participants. It is not testing a specific drug or treatment.
What's involved
You will be asked to complete a medical/family history questionnaire and provide a blood sample. Some participants may also provide a urine sample, and researchers may save biological samples collected during clinical procedures for research. You will also be asked for permission to access your medical records and to be recontacted for updates.
Compensation
Not stated in the trial record.
Follow-up
The data will be used in cohort association studies, with endpoints measured at 10 years.

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NCT00912717

Pancreatic Adenocarcinoma Gene Environment Risk Study

Recruiting
Not specifiedAges 18+Observational
University of Pittsburgh
~10,000 participants
Updated 2025-11-19 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
The data will be used in cohort association studies. Endpoints will depend on the number of patients in the study and the number of markers that are being evaluated.
Measured over 10 years
Pancreatic Cancer
1 sites across 1 states
Pennsylvania1
  • Randall E Brand, MD · PRINCIPAL_INVESTIGATOR · University of Pittsburgh

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Eligibility criteria

Inclusion

Histologically confirmed or CT confirmed diagnosis of pancreatic adenocarcinoma
Subjects with abnormal imaging study (CT, MRI, MRCP, EUS)
Control subjects with a clinical diagnosis of a pancreas, liver, or intestinal condition
Control subject with acute pancreatitis
Control subject with chronic pancreatitis
Control subject with biliary obstruction
Control subject with pancreatic cyst
Member of a high risk family (≥ 1 close relative with pancreatic cancer)
Healthy control (without any of the above conditions)

Exclusion

Under the age of 18 years
Unable to give informed consent
Inability to travel to Pittsburgh for in-person enrollment
  • The data will be used in cohort association studies. Endpoints will depend on the number of patients in the study and the number of markers that are being evaluated.10 years