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Understanding Insulin Secretion After Gastric Bypass Surgery

This study is investigating how gastric bypass surgery affects insulin secretion, especially in people who experience low blood sugar (hypoglycemia) afterwards. Researchers are using three interventions: Exendin-(9-39), Atropine, and GLP-1 and GIP, to understand the roles of gut hormones and nerve signals. They want to see how these factors contribute to insulin release and how the body handles sugar. You might be able to join if you are between 18 and 65 years old and have had gastric bypass surgery with or without hypoglycemia, or if you are a healthy person who hasn't had surgery. The study aims to understand how these factors affect insulin secretion and glucose tolerance. The current status of this study is unclear.

Study design
This interventional study plans to enroll 160 participants. It is designed to evaluate the effects of specific drugs on insulin secretion and glucose metabolism.
What's involved
Each study procedure lasts up to seven hours, with data collected at specific intervals. You would need to be able to come to the clinical research center at Cedars-Sinai Medical Center.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoints are measured during each study procedure, which lasts up to seven hours.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT00992901

Role of Neural and Hormonal Regulation Factors on Insulin Secretion After Gastric Bypass Surgery

Recruiting
EARLY_PHASE1Ages 18–65Interventional
The University of Texas Health Science Center at San Antonio
~160 participants
Updated 2025-09-09 on ClinicalTrials.gov
What's tested:Exendin-(9-39)AtropineGLP-1 and GIP

At a glance

Recruiting sites
2 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Gut hormones and neural signaling contribution to insulin secretion rate and glucose tolerance
Measured over Each study of the protocol is conducted up to seven hours with data collected at intervals specific to the individual study procedure.

Conditions

Post Bariatricsurgery
Hypoglycemia

Explore related trials

Bariatric SurgeryHypoglycemia

Where it's being run

2 sites across 1 states
Texas2

Study leadership

  • Marzieh Salehi, MD, MS · PRINCIPAL_INVESTIGATOR · Marzieh Salehi

Who to contact

Marzieh Salehi, MD MS
[email protected]
210-567-6691
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Hypoglycemic RYGB patients with documented blood glucose level \<50 mg/dl
Asymptomatic individuals with bariatric surgery
Healthy non-surgical patients with no personal history of diabetes
Subjects must physically be able to come to our clinical research center at Cedars-Sinai Medical Center

Exclusion

Active heart, lung, liver, gastrointestinal or kidney disease; unable to give informed consent; pregnancy; uncontrolled high blood pressure or high cholesterol; significant anemia (hemoglobin \<11g/dL); prisoners or institutionalized individuals; type 2 diabetes melitis; development of any serious medical or psychiatric illness during recruitment or studies;
RYGB patients will also be disqualified if they have gastric outlet obstruction or severe diarrhea
Healthy non-surgical patients with personal history of diabetes
History of glaucoma
Uncontrolled hypertension (any subjects with BP\>140/90 and history of dyslipidemia
Taking any medication that might interact with atropine and cannot be stopped will be excluded from the study)
Myasthenia gravis
Brain pathology
Enlarged prostate in men

What this trial measures

  • Gut hormones and neural signaling contribution to insulin secretion rate and glucose toleranceEach study of the protocol is conducted up to seven hours with data collected at intervals specific to the individual study procedure.