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Collecting Samples for Leukemia Research and Immunotoxin Development

This study is collecting human samples like blood, urine, and tissue from people with hairy cell leukemia (HCL), chronic lymphocytic leukemia (CLL), non-Hodgkin's lymphoma (NHL), cutaneous T cell lymphoma (CTCL), and adult T cell lymphoma (ATL), as well as healthy volunteers. Researchers want to understand these conditions better and develop new treatments, especially a type of drug called immunotoxins (an antibody carrying a toxin that kills cancer cells). They are interested in specific genetic changes (biomarkers) like BRAF and BRAF V600E, and how certain cell pathways (mechanisms) like MEK, RAF, and TYROSINE KINASE work. The goal is to acquire these tissue samples within 4 weeks. You can join if you are 18 or older and willing to provide samples and consent.

Study design
This is an observational study, meaning participants are not given specific treatments but rather samples are collected for research. The study plans to enroll 1263 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Tissue acquisition is measured at 4 weeks, but further follow-up is not specified.

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NCT01087333

Collection of Human Samples to Study Hairy Cell and Other Leukemias, and to Develop Recombinant Immunotoxins for Cancer Treatment

Recruiting
Not specifiedAges 18+Observational
National Cancer Institute (NCI)
~1,263 participants
Updated 2026-08-17 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Tissue Acquisition
Measured over 4 weeks

Conditions

Hairy Cell Leukemia (HCL)
Chronic Lymphocytic Leukemia (CLL)
Non-Hodgkins Lymphoma (NHL)
Cutaneous T Cell Lymphoma (CTCL)
Adult T Cell Lymphoma (ATL)

Explore related trials

Adult T-Cell Leukemia/LymphomaChronic Lymphocytic LeukemiaHairy Cell LeukemiaHematologic NeoplasmNon-Hodgkin LymphomaPrimary Cutaneous T-Cell Non-Hodgkin LymphomaSolid Neoplasm

Where it's being run

1 sites across 1 states
Maryland1

Study leadership

  • Robert J Kreitman, M.D. · PRINCIPAL_INVESTIGATOR · National Cancer Institute (NCI)

Who to contact

Julie C Feurtado, R.N.
[email protected]
(301) 480-6186
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

18 years of age and older
Desire of the individual to submit data and samples for research
Ability to understand and the willingness to sign a written informed consent document.
Participants may have a diagnosis of hematologic malignancy or solid tumor. These participants would not be excluded if they were in long-term complete remission.
Individuals must not have a current or prior diagnosis of a hematologic malignancy or solid tumor.

Exclusion

Known pregnancy at enrollment. NOTE: A pregnancy test will be required in individuals on study prior to any procedure done for research purposes that is greater than minimal risk.

What this trial measures

  • Tissue Acquisition4 weeks

    Collection of a variety of clinical samples, including blood, urine, lymphapheresis samples, and other tissues and associated data