Understanding Biomarkers in Transplant Recipients

This observational study aims to better understand how certain proteins (biomarkers) in your body tissues relate to the success of your transplant and the effectiveness of medications used to prevent rejection. Researchers want to see if these biomarkers can help explain how anti-rejection drugs work and the processes that lead to rejection or a rejection-free outcome. The study is looking for 1200 people who have received an organ transplant (abdominal, thoracic) or a bone marrow transplant at the University of Pittsburgh Medical Center. The main goal is to see how often transplant rejection occurs within 90 days after your transplant. The study is currently unclear on its recruitment status.

Study design
This is an observational study, meaning researchers will collect information without giving any specific treatments. It plans to include 1200 participants.
What's involved
You may be asked to provide blood samples during your regular clinical tests, up to 15 ml as many as 7 times in the first year, and then less often. You may also be asked to provide up to 5 ml of saliva no more than four times.
Compensation
Not stated in the trial record.
Follow-up
The primary outcome of rejection is measured at 90 days post-transplantation. Blood samples will be collected indefinitely to assess biomarker stability.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT01163578

Biomarkers in Transplant Recipients to Improve Outcomes

Recruiting
Not specifiedAll AgesObservational
University of Pittsburgh
~1,200 participants
Updated 2026-08-10 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Rejection
Measured over 90 day post transplantation (clinical severity)
Solid Organ Transplantation
Bone Marrow Transplantation

NCT01163578

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Children's Hospital of Pittsburgh of UPMC

    Pittsburgh, Pennsylvaniastudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

  • Rakesh Sindhi, MD · PRINCIPAL_INVESTIGATOR · University of Pittsburgh

Opens a ready-to-send draft in your own email app — review before sending.

Want this trial checked against your situation?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Recipients of abdominal, thoracic and bone marrow allografts that are receiving inpatient and outpatient follow-up with routine laboratory tests at the University of Pittsburgh Medical Center.
All Ages
Subject or parents are able to read and understand the informed consent

Exclusion

Subjects and/or their parents who are unable to read and understand informed consent.
  • Rejection90 day post transplantation (clinical severity)

    Biopsy-proven acute cellular rejection