One-Time DNA Study for Vasculitis

This study aims to find genes that increase the risk of developing vasculitis, which are diseases causing inflammation of blood vessels. Researchers will look at DNA samples and health information from people with conditions like Giant Cell Arteritis and Granulomatosis With Polyangiitis (Wegener's). The goal is to better understand what causes these diseases and to help develop new ways to diagnose and treat them. This is an observational study, meaning no specific treatments are being tested. You may be able to join if you are 7 years or older and have one of the listed vasculitis conditions, with specific diagnostic criteria for Giant Cell Arteritis including age over 50 at disease onset and certain symptoms or blood test results.

Study design
This is an observational study with a planned enrollment of 1000 participants. It is not specified if it is randomized or blinded.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Clinical data and DNA specimens will be evaluated at 1 year.

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NCT01241305

One-Time DNA Study for Vasculitis

Recruiting
Not specifiedAges 7+Observational
University of Pennsylvania
~1,000 participants
Updated 2026-01-22 on ClinicalTrials.gov

At a glance

Recruiting sites
4 of 14 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Evaluation of clinical data and linked DNA specimens.
Measured over 1 year.
Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss)
Giant Cell Arteritis
Granulomatosis With Polyangiitis (Wegener's)
Microscopic Polyangiitis
Polyarteritis Nodosa
Takayasu's Arteritis
14 sites across 11 states
California2
Pennsylvania2
Ontario2
Illinois1
Kansas1
Michigan1
Minnesota1
New York1
  • Peter Merkel, MD, MPH · STUDY_DIRECTOR · University of Pennsylvania

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Diagnosis of GPA or MPA. Widely accepted diagnostic criteria, as opposed to classification criteria or definitions, have not been developed for GPA \& MPA.
For diagnosis of GPA meets at least 2 of the following 5 modified ACR criteria:
For diagnosis of MPA, meets the Chapel Hill Consensus Conference Definition for MPA:

Exclusion

Inability to give informed consent and to sign the consent form
Enrolled in VCRC protocols 5502, 5503, 5504, 5505, 5506, 5522, or 5523
Unwilling to provide blood for DNA collection
  • Evaluation of clinical data and linked DNA specimens.1 year.