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Developing Brain and Muscle Imaging Techniques

This study aims to improve how we use Magnetic Resonance Imaging (MRI) and Magnetic Resonance Spectroscopy (MRS) to look at brain and muscle chemistry. Researchers are testing new ways to use a powerful 7 Tesla MRI scanner and a special head coil (1Tx x 32Rx Head Coil) to get clearer pictures of chemicals in the body. The main goal is to make sure the MRS images are high quality, with good signal and clear details. You might be able to join if you are a healthy adult between 18 and 65 years old. The study is looking for 300 participants.

Study design
This is an interventional study, meaning participants will receive a specific intervention. It plans to enroll 300 healthy volunteers.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary outcome (quality of MR spectroscopy) is measured at prospective and ongoing time points.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT01266577

Development of Magnetic Resonance Spectroscopic Imaging Techniques for Imaging Metabolites in Human Brain and Muscle

Recruiting
NAAges 18–65InterventionalBasic science
National Institute of Mental Health (NIMH)
~300 participants
Updated 2026-08-24 on ClinicalTrials.gov
What's tested:NSR MAGNETOM 7T1Tx x 32Rx Head Coil

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
The primary outcome is the quality of the MR spectroscopy which includes spectrum signal-to-noise (SNR) ratio, spectral lineshape, linewidth, and resolution.
Measured over prospective and ongoing

Conditions

Brain Mapping
Healthy Volunteer

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Healthy Volunteer

Where it's being run

1 sites across 1 states
Maryland1

Study leadership

  • Li An, Ph.D. · PRINCIPAL_INVESTIGATOR · National Institute of Mental Health (NIMH)

Who to contact

Christopher S Johnson
[email protected]
(301) 402-6695
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

18-65 years of age
able to give written informed consent
healthy based on medical history and physical exam
enrolled in Protocol 01-M-0254 or Protocol 17-M-0181

Exclusion

Any current Axis 1 diagnosis
Clinically significant laboratory abnormalities
Positive HIV test
Metallic foreign bodies that would be affected by the magnetic resonance imaging (MRI) magnet, or fear of enclosed spaces likely to make the subject unable to undergo an MRI scan.
History of neurological illness or injury with the potential to affect study data interpretation, such as multiple sclerosis, Parkinson s disease, seizure disorder or traumatic brain injury
Inability to lie flat on camera bed for about two and a half hours
Pregnant or breastfeeding
Current substance use disorder based on DSM-5
NIMH employees and staff and their immediate family members will be excluded from the study per NIMH policy.

What this trial measures

  • The primary outcome is the quality of the MR spectroscopy which includes spectrum signal-to-noise (SNR) ratio, spectral lineshape, linewidth, and resolution.prospective and ongoing

    to obtain more accurate and reliable MRS data from the human brain and muscle