Surgery for Drug-Resistant Epilepsy

This observational study is looking at surgery as a treatment for epilepsy that doesn't respond to medication (drug-resistant epilepsy). Researchers want to understand how well surgery works for children and adults with this condition, or for those with epilepsy caused by a tumor. The study will collect information from people who receive standard epilepsy surgery care. Success will be measured by observing the outcomes of surgery over one year. This study is open to people aged 8 to 99 years old who have drug-resistant epilepsy or tumor-related epilepsy. The study status is currently unclear, and it aims to include about 300 participants.

Study design
This is an observational study, meaning researchers will collect data from people receiving standard epilepsy care. It aims to include about 300 participants.
What's involved
You would undergo standard diagnostic and surgical procedures for epilepsy, which may include invasive monitoring with electrodes.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for one year after treatment.

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NCT01273129

Surgery as a Treatment for Medically Intractable Epilepsy

Recruiting
Not specifiedAges 8–99Observational
National Institute of Neurological Disorders and Stroke (NINDS)
~300 participants
Updated 2026-08-24 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Descriptive and/or correlational studies
Measured over 1 year
Epilepsy
Epilepsy, Temporal Lobe
Partial Epilepsy
1 sites across 1 states
Maryland1
  • Kareem A Zaghloul, M.D. · PRINCIPAL_INVESTIGATOR · National Institute of Neurological Disorders and Stroke (NINDS)

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  • Descriptive and/or correlational studies1 year

    By providing standard care treatment for patients with drug resistant epilepsy, this protocol allows for descriptive and/or correlational studies based on the data collected through clinical care of these patients including neurophysiological correlates of cognitive function and studies of tissue sample acquired during surgery. Outcomes for patients with tumor related epilepsy will be assessed under a separate protocol, 16-N-0041, Tumor Related Epilepsy.