Environmental Risk Factors for Anti-synthetase Syndrome

This observational study is looking into environmental factors that might contribute to myositis, specifically a type called anti-synthetase syndrome. Researchers believe that autoimmune diseases like myositis, which causes muscle weakness, can develop when the body reacts to certain environmental factors. This study aims to find out if specific non-infectious environmental exposures are more common in people who have recently developed anti-synthetase syndrome compared to people without autoimmune diseases. They are also comparing these exposures to people with other recent-onset myositis. The study plans to enroll 580 participants between 2 and 100 years old. To join, you must have a diagnosis of myositis (polymyositis, dermatomyositis, or juvenile forms) confirmed within the last 24 months. The study's success will be measured by whether these environmental exposures are found to be more frequent in the anti-synthetase syndrome group. The current status of this study is unclear.

Study design
This is an observational study, meaning researchers will be looking at information about people without giving them any specific treatments. It aims to enroll 580 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint is measured at enrollment, focusing on exposures prior to disease.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT01276470

Environmental Risk Factors for the Anti-synthetase Syndrome

Recruiting
Not specifiedAges 2+Observational
National Institute of Environmental Health Sciences (NIEHS)
~580 participants
Updated 2026-06-12 on ClinicalTrials.gov

At a glance

Recruiting sites
2 of 8 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
To determine whether selected noninfectious environmental exposures are more common prior to disease in recent-onset pts. w/anti-sythetase syndrome compared w/controls w/o autoimmune disease (1:1 matched with the pts.) and compared w/recent-onse...
Measured over Enrollment
Myositis
Dermatomyositis
Polymyositis
Juvenile Dermatomyositis
Juvenile Polymyositis
8 sites across 6 states
Maryland3
Florida1
Massachusetts1
Minnesota1
North Carolina1
Pennsylvania1
  • Adam I Schiffenbauer, M.D. · PRINCIPAL_INVESTIGATOR · National Institute of Environmental Health Sciences (NIEHS)

Opens a ready-to-send draft in your own email app — review before sending.

  • To determine whether selected noninfectious environmental exposures are more common prior to disease in recent-onset pts. w/anti-sythetase syndrome compared w/controls w/o autoimmune disease (1:1 matched with the pts.) and compared w/recent-onse...Enrollment

    Environmental Questionnaire (EQ) and Child Environmental Questionnaire (CQ)