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Understanding Organ Failure Risk in Severe Sepsis

This observational study is looking at how changes in "alveolar dead space" (areas in the lungs that are ventilated but not involved in gas exchange) might help predict if someone with severe sepsis (a life-threatening response to infection) will develop multi-organ failure. Researchers are using new ventilator technology to quickly measure alveolar dead space in adults with severe sepsis or septic shock who are on a breathing machine. The study aims to see if these measurements can help doctors understand the risk of organ failure earlier. You could join if you are an adult with severe sepsis or septic shock on a breathing machine, admitted to the ICU within the last six hours. The study will track whether participants develop multi-organ failure over two weeks.

Study design
This is an observational study involving about 30 participants. It is not testing a new treatment but rather observing how a specific lung measurement relates to organ failure.
What's involved
You would be followed daily for the first 48 hours in the ICU, then once a week for two weeks, as long as you are on a breathing machine.
Compensation
Not stated in the trial record.
Follow-up
Participants are followed for up to two weeks while on mechanical ventilation, with multi-organ failure measured daily for 48 hours then weekly for two weeks.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT01315782

Alveolar Dead Space as Predictor of Organ Failure in Severe Sepsis

Not Yet Recruiting
Not specifiedAges 18+Observational
The University of Texas Health Science Center, Houston
~30 participants
Updated 2025-06-11 on ClinicalTrials.gov

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Multi-organ failure
Measured over daily for 48 hours then weekly for 2 weeks.

Conditions

Sepsis
Severe Sepsis
Septic Shock
Multi-organ Failure

Explore related trials

Multiple Organ FailureSepticemia

Where it's being run

1 sites across 1 states
Texas1

Study leadership

  • Rosa M Estrada-Y-Martin, MD MSc · PRINCIPAL_INVESTIGATOR · The University of Texas Health Science Center, Houston

Who to contact

Rosa M Estrada-Y-Martin, MD MSc
[email protected]
713-500-6830
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Adults with severe sepsis or septic shock on mechanical ventilation
Enrolled in the initial six hours of ICU admission

Exclusion

Patients with withdrawal or hospice order.
Patients with terminal, irreversible disease, expect to decease in 48 hours from ICU admission.
Patients with COPD.
Patients transferred from outside ICU with ongoing sepsis management for more than six hours.

What this trial measures

  • Multi-organ failuredaily for 48 hours then weekly for 2 weeks.

    Multi-oran failure will be accessed by daily laboratory data, heart function by echocardiogram if available, urinary output, vitals and use of vasopressors.