This study aims to understand why some people get frequent, severe, or unusual fungal infections like Chronic Mucocutaneous Candidiasis (a persistent yeast infection) or Invasive Aspergillosis (a serious lung infection). Researchers believe these infections are linked to problems with the immune system (your body's defense against illness). They will collect medical information, blood, saliva, and possibly tissue samples from people with these infections, their family members, and healthy volunteers. The goal is to identify the specific immune system issues that make people vulnerable to fungal infections. This is an observational study, meaning no new treatments are being tested, and it plans to enroll up to 1200 participants of all ages.

Study design

This is an observational study, not testing any specific intervention. It plans to include up to 1200 participants.

What's involved

You would undergo evaluations including a history/physical exam and provide blood, saliva, and possibly tissue samples for genetic and immunological testing.

Compensation

Not stated in the trial record.

Follow-up

Immunological mechanisms of fungal susceptibility will be measured at 25 years.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.