New Heart Imaging Techniques to Evaluate Possible Heart Disease
This study is testing new ways to use MR Imaging Techniques (magnetic resonance imaging) to get clearer pictures of your heart and blood vessels. The goal is to improve how doctors diagnose heart disease and conditions that can lead to heart attacks, without using radiation. Researchers want to develop and improve these imaging methods to better see the structure of your arteries, how flexible they are, and how well they function. They will also look for early signs of artery problems linked to atherosclerosis (a condition where plaque builds up inside your arteries). You may be able to join if you are between 18 and 100 years old, with or without a history of heart disease, and have varying levels of risk factors for heart conditions.
- Study design
- This interventional study plans to enroll 4000 participants into four groups based on their risk for coronary heart disease (CHD). All groups will undergo multiple small studies using different MR imaging methods.
- What's involved
- Participants will undergo a series of multiple small discovery studies to evaluate different MR imaging methods. The primary endpoints will be measured within one month.
- Compensation
- Not stated in the trial record.
- Follow-up
- Measurements for the study's main goals will be taken within one month.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
New Heart Imaging Techniques to Evaluate Possible Heart Disease
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Ahmed M Gharib, M.D. · PRINCIPAL_INVESTIGATOR · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Who to contact
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What this trial measures
- To develop and optimize clinical imaging protocols and techniques for fast high- resolution coronary MRA and wall imaging for the assessment of coronary and other main arteries structural distensibility, and endothelial functional parameters@...within one month
The accelerated High-resolution MRA results will be compared to conventional angiography and/or computerized tomography angiography (CTA). High- resolution lumen dimensions will be compared to black- blood lumen measurements as well. It is expected that the MRA findings from the 3T scanner will demonstrate image quality that is nearly equivalent to the quality of the coronary arteries visualized using CTA and/or conventional coronary catheterization. Three- dimensional arterial dilatation mapping, representing endothelial function status, will be rendered and visualized
- To evaluate early MR imagery signs of arterial structural, distensibility, and endothelial functional disorders associated with atherosclerosis in a cohort of patients with known or suspected coronary atherosclerosiswithin one month
It is expected that the evaluation of the relationship among these risk factor and imaging variables will find relationships that can be further explored. This study is expected to find information in the data analysis that can be used to generate hypotheses for future testing.
- To develop, implement, and optimize new non-invasive methods for characterization of the micro-environment in the thoracic and abdominal area utilizing specialized techniqueswithin one month
to develop, implement, and optimize new non-invasive methods for characterization of the micro-environment in the thoracic and abdominal area utilizing specialized techniques such as MR Spectroscopy, MR Elastography, and blood oxygenation level dependent (BOLD) imagingThe MRS, MRE and BOLD and other sequences results will be compared to conventional biopsy. It is expected that these advanced sequences will enable non-invasive evaluation and better understanding of various disease processes.