Congenital Muscle Disease Study of Patient and Family Reported Medical Information

This observational study, called CMDPROS, is collecting information from patients and their families about congenital muscle diseases. It aims to understand how these conditions affect daily life and identify common problems or events over a 10-year period. The study is looking for people with various types of congenital muscular dystrophy, including those with ITGA7 (Integrin Alpha-7) deficiency and different forms of Alpha-Dystroglycanopathy. To join, you would register with the Congenital Muscle Disease International Registry (CMDIR) online. The goal is to gather enough information to improve care and quality of life for individuals with these rare conditions.

Study design
This is an observational study with a planned enrollment of 4000 participants. It is a longitudinal study, meaning it collects data over a long period.
What's involved
You would register in the Congenital Muscle Disease International Registry (CMDIR) by visiting www.cmdir.org. There is no travel required.
Compensation
Not stated in the trial record.
Follow-up
Participants' outcomes will be measured over a 10-year period.

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NCT01403402

Congenital Muscle Disease Study of Patient and Family Reported Medical Information

Recruiting
Not specifiedAll AgesObservational
Cure CMD
~4,000 participants
Updated 2021-08-09 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Congenital Muscle Disease Patient and Proxy Reported Outcomes
Measured over 10 years
Congenital Muscular Dystrophy With ITGA7 (Integrin Alpha-7) Deficiency
Alpha-Dystroglycanopathy (Congenital Muscular Dystrophy and Abnormal Glycosylation of Dystroglycan With Severe Epilepsy)
Alpha-Dystroglycanopathy (Congenital Muscular Dystrophy With Fatty Liver and Infantile-onset Cataract Caused by TRAPPC11 Mutations)
Alpha-Dystroglycanopathy (Congenital Muscular Dystrophy With Hypoglycosylation of Dystroglycan)
Alpha-Dystroglycanopathy (Congenital Muscular Dystrophy With Hypoglycosylation of Dystroglycan and Epilepsy)
Alpha-Dystroglycanopathy (Dystroglycanopathy, Congenital With or Without Mental Retardation (Formerly MDC1C))
Alpha-Dystroglycanopathy (Fukuyama CMD)
Alpha-Dystroglycanopathy (LGMDR09 FKRP Related (Formerly LGMD2I))
Alpha-Dystroglycanopathy (LGMDR11 POMT1 Related (Formerly LGMD2K))
Alpha-Dystroglycanopathy (LGMDR13 FKTN Related (Formerly LGMD2M))
Alpha-Dystroglycanopathy (LGMDR14 POMT2 Related (Formerly LGMD2N))
Alpha-Dystroglycanopathy (LGMDR15 POMGnT1 Related (Formerly LGMD2O))
Alpha-Dystroglycanopathy (LGMDR19 GMPPB Related (Formerly LGMD2T))
Alpha-Dystroglycanopathy (LGMDR20 ISPD Related (Formerly LGMD2U))
Alpha-Dystroglycanopathy (LGMDR24 POMGnT2 Related)
Alpha-Dystroglycanopathy (Muscle Eye Brain Disease (MEB))
Alpha-Dystroglycanopathy (Walker Warburg Syndrome (WWS))
Choline Kinase B Receptor - CHKB
Collagen VI Related Disorders
Collagen XII Related Disorders
Congenital Muscular Dystrophy Not Otherwise Specified (Including Merosin Positive)
Congenital Muscular Dystrophy With Cataracts and Intellectual Disability (MDCCAID)
Congenital Muscular Dystrophy With Joint Hyperlaxity
Congenital Muscular Dystrophy With Rigid Spine Related to ACTA1
Emery-Dreifuss Muscular Dystrophy
GOLGA2-related Congenital Muscle Dystrophy With Brain Involvement
LMNA Related Disorders
Merosin Deficient CMD (Full or Partial)
Nesprin Related MD (SYNE1)
SELENON Related Disorders (Previously Known as SEPN1)
SELENON Related Myopathy (Aka SEPN1)
Telethonin CMD
Congenital Myasthenic Syndrome
Limb-Girdle Muscular Dystrophy
LGMDD01 - DNAJB6 (Formerly LGMD1D)
LGMDD05 - Collagen VI Related Bethlem Myopathy (Dominant)
LGMDR07 - Telethonin (TCAP) Related (Formerly LGMD2G)
LGMDR08 - TRIM Related (Formerly LGMD2H)
LGMDR09 - FKRP Related (Formerly LGMD2I)
LGMDR10 - Titin (TTN) Related (Formerly LGMD2J)
LGMDR11 - POMT1 Related (Formerly LGMD2K)
LGMDR13 - Fukutin (FKTN) Related (Formerly LGMD2M)
LGMDR14 - POMT2 Related (Formerly LGMD2N)
LGMDR15 - POMGnT1 Related (Formerly LGMD2O)
LGMDR16 - DAG1 Related Dystroglycanopathy (Formerly LGMD2P)
LGMDR17 - Plectin (PLEC) Related (Formerly LGMD2Q)
LGMDR18 - TRAPPC11 Related (Formerly LGMD2S)
LGMDR19 - GMPPB Related (Formerly LGMD2T)
LGMDR20 - ISPD Related (Formerly LGMD2U)
LGMDR22 - Collagen VI Related Bethlem Myopathy (Recessive)
LGMDR23 - LAMA2 Related
LGMDR24 - POMGnT2 Related
1 sites across 1 states
California1
  • Gustavo Dziewczapolski, PhD · STUDY_CHAIR · CureCMD, CMDIR

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  • Congenital Muscle Disease Patient and Proxy Reported Outcomes10 years

    Correlation between genetic and biopsy findings and their relation to phenotypic and adverse event data.