This study is looking at whether adding minocycline to amiodarone can help prevent atrial fibrillation (an irregular heartbeat) after heart surgery. Atrial fibrillation is a common issue after these surgeries and can lead to more health problems. Researchers want to see if minocycline, an older antibiotic that may help prevent cell death in the heart, can improve upon amiodarone alone. You may be able to join if you are an adult (18 years or older) having certain heart operations, such as coronary artery bypass graft (CABG) or valve repair/replacement. The study will measure how many people develop atrial fibrillation within 6 weeks after surgery. The current status of this study is unclear.

Study design

This interventional study plans to enroll 60 participants. It compares two treatment groups: amiodarone alone versus amiodarone combined with minocycline.

What's involved

You would receive either oral amiodarone for 14 days, or intravenous minocycline for 5 days combined with oral amiodarone for 14 days. Your participation would last for 6 weeks.

Compensation

Not stated in the trial record.

Follow-up

Participants will be followed for 6 weeks after surgery to measure the occurrence of atrial fibrillation.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.