Genetic Analysis for Cancer Treatment Side Effects

This study aims to understand how your genes might affect your body's response to cancer treatments, including potential side effects or how well treatments work. Researchers will collect a blood or cheek swab sample from you to analyze your DNA. They are looking for genetic differences that could explain why some people react differently to cancer medications. This information could help doctors personalize cancer treatments in the future. You can join if you are at least 3 years old, have cancer, and are currently receiving treatment as part of an NIH intramural research program clinical trial. The study is ongoing and plans to include 1100 participants.

Study design
This is an observational study that plans to enroll 1,100 participants. It is an exploratory study designed to look for connections between genetic variations and how the body handles medications.
What's involved
You will provide a blood sample for analysis. If you have blood-based cancer, you will provide a cheek swab sample instead. An additional sample may be collected if the first one doesn't have enough genetic material.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint, which is obtaining and analyzing genomic DNA, is measured at the duration of the study.

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NCT01441089

Collection of Blood From Patients With Cancer, Other Tumors, or Tumor Predisposition Syndromes for Genetic Analysis

Recruiting
Not specifiedAges 3+Observational
National Cancer Institute (NCI)
~1,100 participants
Updated 2026-08-28 on ClinicalTrials.gov

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Obtain and analyze the genomic DNA from patients with cancer, other tumors, or possible genetic tumor predisposition syndromes on a therapeutic clinical trial.
Measured over duration of study
Prostate Cancer
Breast Cancer
Lung Cancer
Ovarian Cancer
Lymphoma
1 sites across 1 states
Maryland1
  • William D Figg, Pharm.D. · PRINCIPAL_INVESTIGATOR · National Cancer Institute (NCI)

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Eligibility criteria

Inclusion

Any individual currently enrolled in an NIH intramural research program clinical trials receiving treatment.
Ability of participant or Legally Authorized Representative (LAR) to understand and be willing to sign the informed consent document.
Age \>= 3 years old

Exclusion

N/A
  • Obtain and analyze the genomic DNA from patients with cancer, other tumors, or possible genetic tumor predisposition syndromes on a therapeutic clinical trial.duration of study

    to determine the association between SNP parameters and clinical response and/or toxicity from genomic DNA extracted from patient samples