Assessment of Eloquent Function in Brain Tumor Patients
This observational study is looking at how well different brain mapping techniques can identify important brain functions (like speech or movement) in people with brain tumors. Researchers will use brain mapping (a diagnostic test that shows brain activity) before, during, and after surgery to see how these functions are affected by the tumor and its removal. The study aims to understand how the brain reorganizes itself after surgery. You may be able to join if you are 19 or older, have a primary or metastatic brain tumor in or near an "eloquent" brain region (an area responsible for important functions), and are able to participate in mapping procedures. The main goal is to measure your brain function one year after surgery.
- Study design
- This is an observational study planning to enroll 75 participants. It does not involve new treatments but rather observes how existing diagnostic tools work.
- What's involved
- You would undergo pre-operative evaluations including clinical exams, neuropsychological tests, MRI, fMRI, DTI, and MEG studies. During surgery, awake mapping will be performed. Post-surgery, you'll have routine follow-up, and repeat neuropsychological testing and mapping studies at 2 and 6 months.
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants will be followed for at least one year, with brain function measured at that time.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Assessment of Eloquent Function in Brain Tumor Patients
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Michele Aizenberg, MD · PRINCIPAL_INVESTIGATOR · University of Nebraska
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- Eloquent function1 year
The location of the eloquent function of interest (motor, sensory, speech) will be assessed pre-operatively and intra-operatively and compared. Then, at 2 and 6 months post-operatively, repeat non-invasive mapping studies will be performed to compare to the subjects' prior studies. This will allow for assessment of reorganization and plasticity of function. Additionally, novel ways of identifying eloquent brain regions will be developed.