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Ovarian Tissue Cryopreservation for Fertility Preservation

This study is exploring a way to help women at risk of losing their fertility, often due to cancer treatments or certain medical conditions. It involves freezing ovarian tissue (cryopreservation) for future use, potentially to mature eggs in a lab (in vitro maturation) or to transplant the tissue back into the body. The goal is to help you have a genetically related child later. You may be eligible if you are a premenopausal woman, aged 0-45, facing treatments like high-dose chemotherapy or surgery that could cause premature menopause or ovarian failure. Success will be measured by the ability to cryopreserve the ovarian tissue, with ovarian function tested 6 months to a year after surgery. The current status of this study is unclear.

Study design
This is an interventional study, meaning participants will receive a specific treatment or procedure. It aims to enroll 300 participants.
What's involved
You would undergo a preoperative ultrasound and blood tests to check ovarian function. If eligible, you would have surgery (laparotomy or laparoscopy) to remove one or both ovaries. You may also have infectious disease testing.
Compensation
Not stated in the trial record.
Follow-up
Your ovarian function will be tested with hormone levels 6 months to a year after surgery.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT01558544

Cryopreservation of Ovarian Tissue

Recruiting
NAUp to 45Interventional
Weill Medical College of Cornell University
~300 participants
Updated 2025-12-10 on ClinicalTrials.gov
What's tested:surgery to remove ovaries or high dose chemotherapy

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
CRYOPRESERVATION OF OVARIAN TISSUE FOR POTENTIAL IN VITRO MATURATION OR AUTOLOGOUS TRANSPLANTATION
Measured over 6 months to a year post surgery, hormone testing will be performed to test ovarian function.

Conditions

Cancer
Risk of Premature Ovarian Failure
Fertility Preservation

Explore related trials

Malignant NeoplasmPremature Menopause

Where it's being run

1 sites across 1 states
New York1

Study leadership

  • Glenn Schattman, MD · PRINCIPAL_INVESTIGATOR · Weill Medical College of Cornell University

Who to contact

Rodriq E. Stubbs, NP
[email protected]
646-962-3276
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Females 0-45 years of age who are premenopausal
Treatment plan that will likely result in premature menopause or premature ovarian failure
This includes patients receiving:
Cancer treatment with abdominal pelvic irradiation and/or high dose chemotherapy
Surgery that requires removal of ovaries for medical condition or disease, e.g. Prophylactic oophorectomy in BRCA patients
Patient is unable or unwilling to pursue fertility preservation by freezing oocytes or embryos.
Previous treatment for cancer is acceptable if patient still has ovarian function
Patient is medically stable enough to undergo surgery (cleared for anesthesia)

Exclusion

Patients not meeting the above criteria
Patients who have not received medical clearance from their physicians to undergo surgery
Patients already experiencing menopause.

What this trial measures

  • CRYOPRESERVATION OF OVARIAN TISSUE FOR POTENTIAL IN VITRO MATURATION OR AUTOLOGOUS TRANSPLANTATION6 months to a year post surgery, hormone testing will be performed to test ovarian function.

    Ovarian tissue cryopreservation Survival of tissue undergoing cryopreservation, thawing and maturation of immature eggs.