Deep Brain Stimulation Surgery for Movement Disorders

This study is looking at Deep Brain Stimulation (DBS) surgery for people with Parkinson's Disease, Essential Tremor, and Dystonia. DBS uses a device called a Medtronic Activa Tremor Control System, which is like a pacemaker, to send electrical signals to the brain to help control movement problems. Researchers want to understand how this surgery affects these conditions and to gather information about brain function during the surgery. You may be able to join if you are 18 or older, have one of these conditions, and your doctor believes DBS is a suitable treatment for you. The main goal is to see how well DBS surgery works for movement disorders after 3 months. The study is currently unclear on its recruitment status and plans to enroll 200 participants.

Study design
This is an interventional study, meaning participants will receive a specific treatment. It is designed to enroll 200 participants.
What's involved
The study involves receiving standard Deep Brain Stimulation surgery. Researchers will collect data on brain function during the surgery and assess your physiology and the surgery's effectiveness at 3 months.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoints for this study are measured at 3 months after the surgery.

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NCT01581580

Deep Brain Stimulation Surgery for Movement Disorders

Recruiting
NAAges 18–99InterventionalTreatment
National Institute of Neurological Disorders and Stroke (NINDS)
~200 participants
Updated 2026-08-28 on ClinicalTrials.gov
What's tested:Medtronic Activa Tremor Control SystemDeep Brain Stimulation

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
physiology and efficacy of DBS surgery for movement disorders
Measured over 3 months
Parkinson's Disease
Essential Tremor
Dystonia
1 sites across 1 states
Maryland1
  • Kareem A Zaghloul, M.D. · PRINCIPAL_INVESTIGATOR · National Institute of Neurological Disorders and Stroke (NINDS)

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Eligibility criteria

Inclusion

idiopathic PD not adequately controlled with medication or
primary dystonia that is medically refractory, or
ET that is not adequately controlled by medications or constitutes a significant functional disability.
  • physiology and efficacy of DBS surgery for movement disorders3 months

    change in UPDRS III scale, Burke-Fahn-Marsden (BFM) scale, and Tremor Rating Scale