Evaluating New Radiation Techniques for Cardiovascular Imaging

This study is looking at new ways to use the Cannon Aquilion ONE CT system for heart imaging. The goal is to see if these new techniques can accurately detect serious blockages in your heart arteries (coronary artery stenosis) using lower radiation doses. Researchers also want to find out if these low-dose scans can predict your risk of future heart problems like heart attacks or death. This study is for people aged 18 to 100 who need a heart CT scan and are willing to provide follow-up information. The main goal is to compare how often heart-related events happen in people with significant blockages versus those with less severe blockages.

Study design
This is an interventional study planning to enroll 5000 participants. It is testing a medical device, the Cannon Aquilion ONE CT system.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed to compare time-to-first cardiovascular events, measured on an ongoing basis.

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NCT01621594

Evaluating New Radiation Techniques for Cardiovascular Imaging

Recruiting
NAAges 18+InterventionalDiagnostic
National Heart, Lung, and Blood Institute (NHLBI)
~5,000 participants
Updated 2026-08-31 on ClinicalTrials.gov
What's tested:Cannon Aquilion ONE CT system

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Compare time-to-first cardiovascular events (death, revascularization more than 90 days after CTA, hospitalization, non-fatal myocardial infarction, stroke) in subjects with >=50% coronary stenosis vs. <50% stenosis.
Measured over ongoing
Coronary Disease
1 sites across 1 states
Maryland1
  • Marcus Y Chen, M.D. · PRINCIPAL_INVESTIGATOR · National Heart, Lung, and Blood Institute (NHLBI)

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  • Compare time-to-first cardiovascular events (death, revascularization more than 90 days after CTA, hospitalization, non-fatal myocardial infarction, stroke) in subjects with >=50% coronary stenosis vs. <50% stenosis.ongoing

    The purpose of this research study is to learn whether these new imaging methods are accurate or predict subject outcomes.